European Archives - Page 1109 of 1134 - European Medical Journal

The Multiple Facets of Thrombotic Microangiopathies

The Alexion satellite symposium was introduced by Prof Pier Mannuccio Mannucci who provided an introduction to the history of thrombotic…

The Standard of Care in Relapsed Refractory CD30+ Lymphoma

CD30-positive (CD30+) lymphomas are a heterogeneous group of hematological malignancies that share the same antigen. Over recent decades, advances…

Overcoming Immunodeficiency in Chronic Lymphocytic Leukaemia: Current Knowledge and Perspectives

While the standard of care for chronic lymphocytic leukaemia (CLL) leads to high overall response rates and a long progression-free survival, it can be…

The Role of CD49d in Chronic Lymphocytic Leukaemia: Microenvironmental Interactions and Clinical Relevance

Chronic lymphocytic leukaemia (CLL) is a clinically heterogeneous disease characterised by the accumulation/expansion of a clonal population of…

Current Developments and Perspectives in Multiple Myeloma

In the last decades, advances in the therapeutic management of multiple myeloma (MM) with new drug armamentarium and strategies have significantly…

Autologous Stem Cell Transplantation In Multiple Myeloma: Is It Still The Right Choice?

Autologous stem cell transplantation (ASCT) is considered the standard of care for multiple myeloma patients aged <65 years with no relevant…

The Role of JAK2 Mutation in Thrombotic Complications of Chronic Myeloproliferative Neoplasms

Patients diagnosed with myeloproliferative neoplasms (MPNs) often develop thrombotic events as an onset of symptoms or in evolution. The pathogenesis of…

Calreticulin in Myeloproliferative Neoplasms: The Other Side of the Alice Mirror

Calreticulin (CALR), a Ca2+ binding protein mostly localised in the endoplasmic reticulum, regulates Ca2+ homeostasis, chaperones, and other proteins to…

Iron Supplementation for Perioperative Anaemia in Patient Blood Management

In patients undergoing major surgical procedures, preoperative anaemia and perioperative allogeneic blood transfusion (ABT) have been linked to increased…

Looking Back To Our Roots: 80 Years of Wintrobe’s Indices

This year (2014) we are celebrating the 80th anniversary of Dr Maxwell Myer Wintrobe’s pioneer works, one of the most important contributions in clinical…