Acne and Systemic Diseases - European Medical Journal

Acne and Systemic Diseases

Dermatology
Download PDF
Authors:
Tugba Kevser Uzuncakmak, *Ayse Serap Karadag, Necmettin Akdeniz
Disclosure:

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

Received:
09.07.15
Accepted:
03.09.15
Citation:
EMJ Dermatol. ;3[1]:73-78. DOI/10.33590/emjdermatol/10314085. https://doi.org/10.33590/emjdermatol/10314085.
Keywords:
acne vulgaris, hyperandrogenaemia, insulin resistance, systemic diseases

Each article is made available under the terms of the Creative Commons Attribution-Non Commercial 4.0 License.

Abstract

Acne is a very common, multifactorial, complex, and chronic disease of the pilosebaceous unit that affects approximately 85% of adolescent patients and 3% of adult patients. The roles of sebaceous glands, androgens, follicular epithelial cells, Propionibacterium acnes , immune mediators, environmental factors, and genetic factors are well known in acne pathogenesis. Although it is not a life-threatening disease, it is closely associated with low quality of life and psychological depression. Moreover, acne can also be associated with hypovitaminosis, or may present as a part of systemic syndromes such as: congenital adrenal hyperplasia; seborrhoea-acne-hirsutism-androgenetic alopecia syndrome; polycystic ovary syndrome; hyperandrogenaemia, insulin resistance, and acanthosis nigricans syndrome; Apert syndrome; synovitis-acne-pustulosis-hyperostosis-osteitis syndrome; pyogenic arthritis, pyoderma gangrenosum, and acne syndrome; metabolic syndromes; and Behçet’s syndrome. These syndromes must be excluded in patients with severe and recalcitrant acne.

Please view the full content in the pdf above.

Rate this content's potential impact on patient outcomes

Thank you!

Please share some more information on the rating you have given