Contact dermatitis (CD), one of the most common skin disorders, is one of the oldest but, at the same time, one of the newest diseases in dermatology. Ideas about the pathogenic mechanism, clinical aspects, and the therapeutic and prophylactic methods are always at the centre of the discussion; cutaneous barrier and ‘sensitive skin’ are two of the most important subjects when we refer to prophylaxis. We will try to present the connections between sensitive skin terrain, disruption of the skin barrier, and the development of CD. Establishing these connections, and understanding them, can set some valuable prophylactic methods for CD.
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