A RECENT systematic review and meta-analysis has revealed a concerning link between paediatric hidradenitis suppurativa (HS) and a higher prevalence of various comorbidities. HS, a chronic inflammatory skin condition marked by painful nodules in body folds, affects a significant number of children and adolescents. The review encompassed 19 studies involving over 17,000 paediatric HS patients and more than 8 million control subjects, providing a robust dataset for analysis.
The findings indicate that children with HS are significantly more likely to suffer from a range of both physical and mental health conditions compared to those without the disease. Notably, the prevalence of acne vulgaris was 43%, obesity 37%, anxiety 18%, and hirsutism 14% among HS patients. The study also found a moderate level of certainty in the association between paediatric HS and both obesity and depression, and a low level of certainty linking the condition to diabetes.
Importantly, most patients in the included studies were female, with an average of 76.7% being girls, suggesting a possible gender-related predisposition that warrants further investigation. The high rates of psychiatric and metabolic comorbidities in this population point to a substantial burden on affected individuals, which may impact their overall development, social interactions, and long-term wellbeing.
Given these findings, the authors stress the need for comprehensive, multidisciplinary screening and management strategies for young people diagnosed with HS. Early identification and treatment of associated conditions like obesity, anxiety, and depression could lead to better outcomes and an improved quality of life. Moreover, this research supports integrating dermatological care with psychological and general medical services for this vulnerable group.
In summary, the study highlights the significant overlap between paediatric HS and other chronic health conditions, underlining the importance of a holistic approach in the management of these patients. Early intervention and coordinated care could be key to improving long-term health trajectories for children and adolescents living with HS.
Reference
Mohsen ST et al. Prevalence of comorbidities among pediatric patients with hidradenitis suppurativa: a meta-analysis. JAMA Dermatol. 2025;DOI:10.1001/jamadermatol.2025.1565.
