This content was funded and developed by Sanofi for scientific exchange and is intended for healthcare professionals only.
Disclaimer: EMJ has published this infographic on behalf of Sanofi and has had no input in its creation.
- Given the complexity of the underlying inflammation in patients with atopic dermatitis (AD), an increased understanding of the OX40 ligand pathway can improve insight into AD pathogenesis.
- The visual analogy of the inflammatory prequel features a conductor, the violins, violas, cellos, and woodwinds building on one another to amplify their instruments into one written score, similar to how cells of the immune system are recruited and activated to amplify the inflammatory score that drives AD.
- The inflammatory prequel is a foundational driver of immune imbalance, where antigen-presenting cell-driven OX40 ligand signalling leads to dysregulated T cell activity, heterogeneity, and chronicity.
- Click through the visual analogy to learn about the key steps involved in the cycle of inflammation involving T-helper cells, tissue resident memory T cells, cytokines (IL-4, IL-13, IL-5, IL-31, IL-17, and IL-22), and regulatory T cells.
