At the American Diabetes Association’s (ADA) virtual 81st Scientific Session, a symposium was presented wherein Ian J. Neeland, Cleveland, Ohio, USA, discussed the role of intra-organ fat in obesity pathogenesis and Roy Taylor, Newcastle upon Tyne, UK, highlighted how analysis of intra-hepatic and intra-pancreatic fat using MRI can lead to insights into practical therapy for achieving effective weight loss and remission of type 2 diabetes. This article reviews their findings and how weight loss interventions may not only help reduce cardiovascular and metabolic disease risk, but also reverse type 2 diabetes for some patients.
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More than two decades ago, during the 3-year course as a post-graduate trainee of internal medicine and working in the largest medical college of Asia, that too under a renowned diabetologist, I was exposed to handling an extremely busy diabetes clinic catering several hundred patients a day, with a limited backup supporting staff. I think this was the trigger for my keen interest in pursuing post-doctoral course in diabetes and endocrinology. Even during my undergraduate days, there was a notion that if you do not fully know how to treat diabetes and tuberculosis in India, you have not learnt anything about internal medicine. The field of diabetology was set to hold a great promise since a lot was left to be learnt about the complex pathophysiology including the management of Type 2 diabetes mellitus (T2DM).
Interview - Alison McNeilly
I have always been interested in physiology and how the body works, and, during my PhD, I had the opportunity to work with models of glucose dysregulation. Many of us take the ability to control our blood glucose within a ‘healthy euglycaemic’ range for granted. It is only when things go wrong that we appreciate how complex this process is. My recent work has focused on Type 1 diabetes mellitus (T1DM), where individuals cannot produce their own insulin and rely on insulin replacement therapy.