IMMUNE thrombocytopenic purpura (ITP) mortality in the United States has persisted over the past two decades. Disparities remain pronounced, with higher death rates observed among men, non-Hispanic White populations, and individuals living in rural and Midwestern regions, according to new data spanning 1999 to 2022.
Researchers analyzed national mortality records to evaluate age-adjusted mortality rates (AAMR) linked to ITP, an autoimmune condition defined by low platelet counts in the absence of another cause. Over the 24-year period, 17,069 ITP-related deaths were reported across the country. The findings highlight significant demographic and geographic differences in mortality burden.
Men experienced higher overall mortality compared with women, with an AAMR of 0.22 versus 0.17 per 100,000 population. Non-Hispanic White individuals had the highest rates among racial and ethnic groups, registering an AAMR of 0.20. Geographic analysis revealed stark regional variation. Non-metropolitan areas recorded a higher overall AAMR (0.24) compared with metropolitan settings (0.19). The Midwest reported the greatest regional burden with an AAMR of 0.22. Vermont, Rhode Island, and North Dakota were among the states with the highest reported mortality, while Nevada, the District of Columbia, and Louisiana showed the lowest levels.
The study authors note that these patterns likely reflect a combination of healthcare access issues, genetic susceptibility, and variations in treatment practices across regions. The results underline the importance of targeted efforts to address gaps in care, particularly in vulnerable populations such as the elderly and residents of rural communities.
By mapping long-term national trends, the study provides clinicians and policymakers with a clearer understanding of which patient groups face the greatest risks. Efforts to improve early recognition, equitable access to hematology services, and consistent treatment approaches may help reduce ITP-related deaths and close these persistent gaps in outcomes.
Reference: Ahmed S et al. Trends and disparities in immune thrombocytopenic purpura-related mortality in the United States: a retrospective study over 24 years. Hematology. 2025;30(1):2559334.
