Bone marrow failure (BMF) is characterised by a reduction in the effective production of mature erythrocytes, granulocytes, and platelets by the bone marrow that leads to peripheral blood pancytopaenia. In some conditions, only one or two cell lines may be affected. The BMF syndromes include a group of disorders than can be either inherited or acquired. The inherited BMF syndromes include: Fanconi anaemia, dyskeratosis congenita, Diamond-Blackfan anaemia, and other genetic disorders. The most common cause of acquired BMF is aplastic anaemia.
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