Diffuse large B-cell lymphoma (DLBCL) was considered an incurable disease until the introduction of polychemotherapy (e.g., CHOP) in the 1970s. Treatment improved significantly with the introduction of the anti-CD20 antibody, rituximab, in combination with CHOP (R-CHOP), however, one-third of patients are either refractory to this initial treatment or relapse after treatment. Prof Laurie Sehn chaired a symposium as part of the 15th International Congress on Malignant Lymphoma (ICML) in Lugano, Switzerland, discussing the unmet need of DLBCL patients and the future of using antibody therapy.
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von Willebrand factor (VWF) is a large, adhesive, multimeric protein involved in haemostasis. The larger the size (or number of VWF multimers), the greater the functionality of the protein.