Definitions of Acute-On-Chronic Liver Failure: The Past, the Present, and the Future - European Medical Journal

Definitions of Acute-On-Chronic Liver Failure: The Past, the Present, and the Future

Hepatology
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Authors:
*Roland Amathieu,1 Ali Al-Khafaji2
Disclosure:

No potential conflict of interest.

Received:
21.11.14
Accepted:
11.12.14
Citation:
EMJ Hepatol. ;3[1]:35-40. DOI/10.33590/emjhepatol/10310827. https://doi.org/10.33590/emjhepatol/10310827.
Keywords:
Acute-on-chronic liver disease, chronic liver disease, Cirrhosis, classification, definition, Metabolomics

Each article is made available under the terms of the Creative Commons Attribution-Non Commercial 4.0 License.

Abstract

Acute-on-chronic liver failure (ACLF) is an entity used to define patients with liver cirrhosis presenting with acute decompensation. For over 20 years, ACLF has taken multiple definitions and/or  classifications. Unfortunately, to date, there has not been a universally accepted definition/classification  of this entity. In this short review, we discuss the definition evolution of ACLF, the strengths and  weaknesses of the existing definitions and classifications, and finally the potential role of the ‘omic’ approaches for the diagnosis of this complex syndrome.

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