Vascular Calcification in Chronic Kidney Disease: An Update - European Medical Journal
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Vascular Calcification in Chronic Kidney Disease: An Update

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Authors:
Mario Cozzolino,1 Francesco Cosa,2 Paola Ciceri,3 Francesca Elli,4 Flavia Ricca,5 Laura Cappelletti,5 Antonio Bellasi,4 Daniele Cusi6
Disclosure:

No potential conflict of interest.

Citation
EMJ Nephrol. ;1[1]:46-51.

Each article is made available under the terms of the Creative Commons Attribution-Non Commercial 4.0 License.

Abstract

Vascular calcification involves passive degeneration and an active process of arterial mineralisation, resembling osteogenesis. In chronic kidney disease, several proteins that physiologically control bone mineralisation, are also involved in the molecular and cellular mechanisms of the pathogenesis of vascular calcification. In fact, arterial cells grown in culture are induced to become osteogenic by inflammatory and atherogenic stimuli, such as high phosphate concentration. Mechanisms linking them must be considered in clinical decisions. Further understanding of processes causing vascular calcification may be considered for new therapeutic options for vascular disease in renal patients.

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