rof David Goldsmith opened the symposium by highlighting the objectives of the meeting. The education objectives of the symposium were to summarise the mechanisms that regulate potassium balance, specifically highlighting how these mechanisms are affected by inhibition of the renin-angiotensinaldosterone system (RAAS); to examine the pathophysiology of hyperkalaemia and illustrate the impact on clinical outcomes; to evaluate current clinical evidence and outline key considerations that help determine the urgency; and to describe recent clinical trial data on investigational oral ion exchangers and the potential future role of these emerging therapies in clinical practice.
In the first presentation, Prof Johannes F. E. Mann discussed the predisposing factors of hyperkalaemia by presenting a case of a heart failure (HF) patient with Stage 3 chronic kidney disease (CKD), and also discussed the epidemiology and pathophysiology of hyperkalaemia. Dr Martin H. de Borst then discussed the current therapeutic options available for the outpatient treatment of hyperkalaemia, along with recent clinical data on novel treatments, in particular patiromer and zirconium cyclosilicate (known as ZS-9).
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