In this supplement to EMJ Neurology, two leading experts in multiple sclerosis (MS), Prof Tjalf Ziemssen and Prof Diego Centonze, explored the sphingosine 1-phosphate (S1P) receptor modulators drug class and how they can be utilised in the management of patients with MS.
EMJ Neurology 8 [Supplement 2] . 2020
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From CoNFLict to Confidence: Solving a Diagnostic Dilemma Using Neurofilament Light – A Case Report
Measurement of fluid biomarkers of neurodegeneration is an emerging approach offering improved diagnostic accuracy of neuropsychiatric conditions, particularly for atypical presentations. This article reports a case where the diagnosis of delirium with dementia was revised based on biomarker analysis, enabling treatment of a primary mood disorder with resolution of recurrent disabling psychiatric symptoms.
Benzodiazepines in the Treatment of Behavioural and Psychological Symptoms Associated with Dementia and Their Impact on Cognitive Impairment: Review of Clinical Evidence
In the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5), Alzheimer’s disease (AD [named after the German psychiatrist and neuropathologist, Alois Alzheimer, who first described it]), is considered as a major or mild neuro-cognitive disorder. It is estimated that about 50–70% of total dementia cases are due to this condition, while 10–20% are due to vascular dementia, and it is the fourth leading cause of death in industrialised countries.
Editor's Pick: The Pathophysiological Relationship Between Migraine and SARS-CoV-2 Infection: A Comprehensive Literature Review
People with migraine, and individuals with other neurological conditions, have suffered in multiple aspects during the COVID-19 pandemic. This paper will discuss the factors that impacted the neurology department.
Mexiletine in the Treatment of Non-dystrophic Myotonia: Interviews with Six Medical Experts
NDM includes a group of rare hereditary neuromuscular disorders caused by mutations in the genes that encode sodium or chloride muscle channels.1 Myotonia is the hallmark symptom of NDM and presents as muscle stiffness, often associated with pain, fatigue, and weakness, which can limit function.