Alloimmune Thrombocytopaenic Disorders: A Review - European Medical Journal

Alloimmune Thrombocytopaenic Disorders: A Review

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*Sophia Delicou, Marianna Bellia

Both authors declare no support from any organisation for the submitted work; no financial relationships in the previous 3 years with any organisations that might have an interest in the submitted work; and no other relationships or activities that could appear to have influenced the submitted work.

EMJ Oncol. ;3[1]:59-64. DOI/10.33590/emjoncol/10310519.
Thrombocytopaenia, alloimmune, alloantigens.

Each article is made available under the terms of the Creative Commons Attribution-Non Commercial 4.0 License.


Alloimmune thrombocytopaenia (AIT) is caused by alloantibodies against specific platelet glycoproteins. Alloimmune thrombocytopaenic disorders include alloimmune neonatal thrombocytopaenia, posttransfusion purpura, refractoriness to platelet transfusions, passive AIT, and transplantation-associated AIT. In this review we have summarised five thrombocytopaenic syndromes caused by platelet-reactive alloantibodies. Increased awareness of these syndromes, together with the greater availability of highly specialised laboratory methods to detect and to characterise platelet-reactive alloantibodies, will lead to their more frequent diagnosis.

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