OVARIAN cancer is the seventh most commonly diagnosed malignancy among women worldwide, and the gynaecologic cancer with the worst prognosis and highest mortality. This is because of its resistance to common chemotherapeutic agents, vague and non-specific symptoms, and the lack of effective screening strategies for early detection. However, new research has suggested that poly(ADP-ribose) polymerase (PARP) inhibitors could potentially transform the treatment landscape of advanced ovarian cancer.
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Editor’s Pick: More than FOLFOX and FOLFIRI: The Management of Metastatic Colorectal Cancer in the Era of Precision Oncology
Colorectal cancer (CRC) is the second most common cause of cancer-related death in the USA. Despite improvements in screening rates and in the overall survival (OS) of patients with localised and advanced disease over the past few decades, the 5-year OS of patients with metastatic disease is still extremely poor and estimated to be approximately 15%.
Perspectives on Hepatic Metastases and the Minimally Invasive Approach to Resection
The liver is the most common site for colorectal cancer (CRC) metastases, accounting for 80% of patients with Stage IV CRC and 40% as the only site of distant disease. Of the patients with CRC, 20–25% present with synchronous metastases and 50–60% will develop metachronous disease. Liver metastases develop in the absence of lymph node involvement and, presumably, this occurs via the haematogenous route (the portal circulation) in gastrointestinal tumours from where tumour cells can embolise via the mesenteric veins.
Evaluation of Treatment Outcome and Acute Toxicity in Patients Undergoing Adjuvant Therapy in Ductal Carcinoma Pancreas: A Prospective Observational Study
Pancreatic cancer is the eleventh most commonly diagnosed cancer worldwide and is the seventh leading cause of cancer-related death. It can arise from both exocrine (95%) and endocrine portion (5%) of the pancreatic gland. The most common histology is ductal adenocarcinoma of the pancreas, which accounts for around 80% of all pancreatic cancers, while 65% of the cases arise in the pancreatic head, 15% in the body or tail, and 20% involve the gland diffusely.