Mindfulness-Based Stress Reduction Linked to Lower Distress
MINDFULNESS-BASED stress reduction reduced chemotherapy-related nausea, vomiting, depression, and anxiety in patients with colorectal cancer, according to findings from a retrospective cohort study.
The study included 301 patients with colorectal cancer undergoing chemotherapy. Patients in the control group received routine nursing care, while those in the mindfulness-based stress reduction group completed an 8-week intervention incorporating mindful breathing, body scan exercises, and meditation. Symptoms were assessed across four chemotherapy cycles using the Functional Living Index Emesis, Patient Health Questionnaire-9, and Generalized Anxiety Disorder-7.
Reduced Nausea and Vomiting During Chemotherapy
Chemotherapy-induced nausea and vomiting remain common and distressing complications for patients with colorectal cancer, with potential effects on hydration, nutrition, quality of life, and treatment adherence. In this cohort, patients who received mindfulness-based stress reduction had significantly higher nausea and vomiting scores on the Functional Living Index Emesis compared with those receiving routine nursing care, indicating less severe CINV.
The differences were significant across chemotherapy cycles, with all comparisons reported at p<0.001. The findings suggest that mindfulness-based stress reduction may offer a useful supportive care strategy alongside standard antiemetic therapy for patients experiencing chemotherapy-related physical distress.
Anxiety and Depression Scores Also Improved
Psychological distress also improved among patients receiving mindfulness-based stress reduction. PHQ-9 and GAD-7 scores were significantly lower in the intervention group compared with the control group, with p values below 0.001 across assessments.
The mindfulness-based stress reduction group also showed a clear pattern of improvement over time, with both baseline and post-intervention depression and anxiety scores declining throughout the treatment course. This trend suggests that the intervention may provide cumulative psychological benefits as chemotherapy continues.
Supportive Role in Colorectal Cancer Care
The findings highlight the potential value of a structured, nonpharmacologic intervention for addressing both physical and psychological distress in patients with colorectal cancer receiving chemotherapy. By combining mindful breathing, relaxation, body awareness, and meditation, mindfulness-based stress reduction may help patients better manage the symptom burden associated with treatment.
While the retrospective design limits causal interpretation, the results support further evaluation of mindfulness-based stress reduction as part of comprehensive supportive care for patients with colorectal cancer undergoing chemotherapy.
Reference
Huang M et al. The effect of mindfulness-based stress reduction on chemotherapy-related physical and psychological distress in colorectal cancer patients: a retrospective cohort study. Future Oncology. 2026; DOI: 10.1080/14796694.2026.2672133.
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