18F-FET or 18F-FCH PET/CT in the Primary Diagnosis of Low-Grade Glioma: A Pilot Study - European Medical Journal

18F-FET or 18F-FCH PET/CT in the Primary Diagnosis of Low-Grade Glioma: A Pilot Study

1 Mins
*Marina Hodolic,1,2 Ana Misir Krpan,3 Anja Tea Golubic,4 Maja Baucic,3 Jakob Nemir,5 Goran Mrak,5 Marjan Zuvic,4 Drazen Huic4

Prof Hodolic is a medical consultant for IASON. The other authors have declared no conflicts of interest.

EMJ Radiol. ;1[1]:35-37. Abstract Review No. AR6.
Fluoromethyl-(18F)-dimethyl-2-hydroxyethyl-ammonium chloride (FCH), O-(2-[18F]-fluoroethyl)-L-tyrosine (FET), low-grade glioma (LGG), PET/CT.

Each article is made available under the terms of the Creative Commons Attribution-Non Commercial 4.0 License.


Gliomas are associated with variable survival, linked to their histological type.1 Although traditionally gliomas behave as if benign, low-grade gliomas (LGG) gradually evolve into high-grade tumours. Within 5 years, this will occur in approximately one-half of patients.2 The
diagnosis of LGG is challenging because conventional imaging modalities can often give inconclusive or equivocal results.3

Functional imaging modalities can provide additional metabolic information in the management of patients with LGG. O-(2 [18F]-fluoroethyl) -L-tyrosine (18F-FET) is a radiopharmaceutical approved for the characterisation of glioma-suggestive brain lesions.4-6

18F-FET displays a high tumour-to-background ratio and no accumulation in inflammatory lesions. Because of low uptake in normal brain parenchyma, some centres use fluoromethyl-(18F)-dimethyl-2-hydroxyethyl-ammonium chloride (18F-FCH) PET for the characterisation of glioma-suspected brain lesions. The aim of this study was to determine the diagnostic accuracy of 18F-FET and 18F-FCH PET/CT in patients with primary LGG.


11 patients aged 21–80 years with MRI-suspected LGG were involved. Patients underwent both 18F-FET and 18F-FCH PET/CT within 1 week. Brain PET/CT was performed according to standard protocol: 20 min after intravenous injection of 185MBq of 18F-FET and 185MBq of 18F-FCH PET. Surgery and histological diagnoses were performed in the following 2 weeks.

All 11 patients with suspected LGG underwent MRI, 18F-FET, and 18F-FCH PET/CT. All patients had LGG according to MRI. In all PET-positive patients, tumour location on MRI was consistent with region of PET/CT positivity. Two out of 11 patients included in this study did not undergo surgery or biopsy for histological confirmation. Both had negative 18F-FET PET and negative 18F-FCH PET scan, so they declined surgery and multidisciplinary tumour board recommended follow-up. Nine out of 11 patients with suspected LGG had final histological diagnosis after the surgery.


The results of the study are summarised in Table 1. Significantly better concordance was described between tumour histology and 18F-FET PET results (weighted κ: 0.74) compared to both 18F-FCH (weighted κ: 0.15) and MRI results (weighted κ: 0.00). Significant association between tumour histology and 18F-FET results was found (odds ratio: 12.87; 95% confidence interval [CI]: 0.49–333.70; p=0.013, logistic regression analysis). Most patients with histologically-proven LGG had negative 18F-FCH and positive 18F-FET (Figure 1).

Table 1: Diagnostic workout of patients included in the study.

FCH: Fluoromethyl-(18F)-dimethyl-2-hydroxyethyl-ammonium chloride; FET: O- (2-[18F]-fluoroethyl) -L-tyrosine; IDH: isocitrate dehydrogenase; NA: not applicable; NOS: not otherwise specified; SUV max: maximum standard uptake value.

Figure 1: 38-year-old male patient with World Health Organization (WHO) Grade II diffuse astrocytoma.
A) positive 18F-FET PET/CT (SUV max: 2.8); B) negative 18F-FCH PET/CT; and C) MRI of a fast fluid-attenuated inversion recover tumour in right frontal lobe.

FCH: Fluoromethyl-(18F)-dimethyl-2-hydroxyethyl-ammonium chloride; FET: O-(2-[18F]-fluoroethyl)-L-tyrosine; SUV max: maximum standard uptake value.


These results demonstrate that the appropriate radiopharmaceutical should be chosen before performing PET/CT scan in patients with newly diagnosed LGG. The 18F-FET PET/CT is more accurate than 18F-FCH to detect LGG.

Louis DN et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 2016;2131(6):803-20. McKhann GM, Duffau H. Low-grade glioma: epidemiology, pathophysiology, clinical features, and treatment. Neurosurg Clin N Am. 2019;30(1):xiii-xiv. Forst DA et al. Low-grade gliomas. Oncologist. 2014;(4):403-13. Pauleit D et al. O-(2-[18F]fluoroethyl)-L-tyrosine PET combined with MRI improves the diagnostic assessment of cerebral gliomas. Brain. 2005;128(Pt 3):678-87. Floeth FW, Stummer W. The value of metabolic imaging in diagnosis and resection of cerebral gliomas. Nat Clin Pract Neurol. 2005;1(2):62-3. Tanaka Y et al. Glioma surgery using a multimodal navigation system with integrated metabolic images. J Neurosurg. 2009;110(1):163-72.

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