Allergy & Immunology

Mast cells are the central cells in the pathogenesis of many conditions that are associated with mediator release. New information is emerging about the role of mast cells in a number of conditions. This review summarises current knowledge on the topic.

A two-part digital symposium series entitled ‘Hereditary Angioedema (HAE) Management: From Dealing to Leading,’ took place during the European Academy of Allergy and Clinical Immunology (EAACI) Hybrid Congress, held in Prague, Czechia, in July 2022.

Hereditary angioedema (HAE) is a rare but debilitating and potentially fatal disease that presents in various forms, and can be difficult to manage. Its underlying cause is mutations in a gene that, through its protein product, controls production of the tissue enzyme kallikrein and a peptide mediator, bradykinin. The resulting overproduction of bradykinin leads to increased vascular permeability and oedema.

During the COVID-19 pandemic, frequent handwashing and disinfection have exacerbated or caused skin diseases. This case report shows the simultaneous development of allergic contact dermatitis to Kathon CG (DuPoint, Wilmington, Delaware, USA), Euxyl K400, and fragrance mix I because of the frequent use of moist (baby) wipes during the pandemic outbreak.

Allergen-specific immunotherapy (AIT) works well both in children and adults. An often-alleged gap between the level of evidence of AIT efficacy…

Shiitake dermatitis is a rare eruption that is associated with the ingestion of uncooked shiitake mushrooms, resulting in a distinctive…

Allergy development is a complex process and depends on numerous factors, including postnatal influences, that guide the immune system…

The latest international guidelines on urticaria were published in September as a joint initiative from the European Academy of…