Allergy & Immunology

Autoclaving peanuts significantly reduces IgE binding and improves tolerability in peanut-allergic individuals, offering promise for safer immunotherapy approaches.

The basophil activation test may help identify children at risk of severe allergic reactions to cow’s milk, improving safety during oral food challenges.

A Canadian real-world study reveals high oral corticosteroid exposure in patients with severe chronic rhinosinusitis with nasal polyps prior to biologic therapy.

International panel of anaphylaxis experts develops guidance for non-medical personnel to correctly identify patients with acute allergic reactions that require epinephrine administration.  

High airway TSLP levels identify a subset of severe asthma patients with type 2 inflammation, mucus plugging, and airway remodelling despite corticosteroid treatment.

Interview study shows injectable on-demand treatments for hereditary angioedema may delay care and negatively impact quality of life, highlighting demand for oral options.

A clinical trial shows immune-targeted therapy tailored to sepsis subtypes improves organ function by day 9, offering a new approach to treatment.

Very low-dose multi-nut oral immunotherapy significantly increased tolerance in children with multiple nut allergies, with a favourable safety profile and no epinephrine use.