Allergy & Immunology

Researchers identified a distinct population of tissue-resident memory T (TRM) cells expressing IL-17A and/or IL-17F that were largely absent from healthy skin.

Exclusive breastfeeding for at least four months was associated with lower overall odds of asthma up to age 24 years (odds ratio: 0.75; 95% CI: 0.64–0.87).

Londamocitinib produced approximately 50% reductions in fractional exhaled nitric oxide at the 1.4 mg and 3 mg doses.

Importantly, this microbiota–metabolite signature was inversely associated with the development of food allergen-specific IgE up to 5 years of age and with atopic dermatitis at 2 years.

ALA-DAG oil improved skin hydration and reduced allergic symptoms in adults with mild skin discomfort.

After 1 year, 13 of 17 patients in the 30 mg group tolerated at least 443 mg peanut protein, compared with none in the avoidance group. Similar improvements were observed in the 300 mg group.

Autoclaving peanuts significantly reduces IgE binding and improves tolerability in peanut-allergic individuals, offering promise for safer immunotherapy approaches.

The basophil activation test may help identify children at risk of severe allergic reactions to cow’s milk, improving safety during oral food challenges.