Cardiology

Placental abruption linked to increased cardiovascular disease risk in offspring, with effects lasting into adulthood.

These findings suggest that pulmonary arterial hypertension directly disrupts brain homeostasis, potentially driving early neurological damage.

Genetic deletion or pharmacological depletion of NK cells reduced cardiomyocyte death, limited inflammation, and improved cardiac function.

The oral PCSK9 inhibitor achieved a mean LDL-C reduction of -64.6% from baseline, substantially outperforming bempedoic acid (-6.3%), ezetimibe (-27.8%), and combination therapy (-36.5%).

Each doubling of sNfL concentration increased the risk of major vascular events by 35% (adjusted hazard ratio: 1.35; 95% CI: 1.22–1.50; p

The model identified approximately 13% of high-risk individuals who would not have been detected using polygenic risk scores alone.

A classifier trained on pre-diagnostic activity and heart rate metrics demonstrated strong discriminatory ability, distinguishing patients with IPAH from controls with a ROC AUC of 0.87.

The findings showed that videos produced by non-healthcare creators consistently achieved significantly greater numbers of reshares (p=0.0050), favourites (p=0.0495), and overall engagement rates (p=0.0014).