Hematology

A multicentre study of 598 patients with relapsed or refractory multiple myeloma identified distinct high-risk features associated with early and delayed treatment failure following cilta-cel.

CRISPR screens identified 17 genes and 13 genomic regions linked to red blood cell density, providing new insights into how genetic variants influence red blood cell traits.

A meta-analysis of 85 randomised clinical trials found that SGLT2 inhibitors were associated with modest increases in haemoglobin and haematocrit, alongside changes in erythropoietin and transferrin saturation.

Pre-closure intraoperative fibrinogen has been associated with favourable early postoperative haemostasis in patients undergoing spinal deformity surgery.

Hydroxyurea was not associated with increased infection risk in children with sickle cell anaemia, with rates declining through treatment phases.

Venetoclax-based therapy enabled many children with relapsed acute leukaemia to proceed to stem cell transplantation.

A Myeloma-XI analysis identified clinical, tumour and inherited genetic factors associated with arterial thromboembolism risk in multiple myeloma.

Earlier transplantation after high-risk features emerge may improve survival in Shwachman-Diamond syndrome.