Hematology

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Red blood cell transfusion

Blood Transfusion Findings in Preterm Infants

July 2026

A multicentre cohort study found that pretransfusion haemoglobin and anticoagulant preservative solution were associated with outcomes after red blood cell transfusion in very low birth weight infants.

tumour reactive T cells

Multiple Myeloma Immunotherapy Response Tied to T Cell Fitness

A transcriptional classifier identifies tumour reactive T cells in multiple myeloma and predicts response to immunotherapy, offering a potential biomarker for treatment selection.

leukaemia

MEF2C Stability Mechanism Identified in Aggressive AML

A new study identifies a paralog dependency regulating MEF2C stability in acute myeloid leukaemia and demonstrates a peptide approach that suppresses disease progression in preclinical models.

Malaria in Pregnancy Drives Maternal Anaemia Burden

Modelling across seven African countries shows malaria in pregnancy remains a major cause of maternal anaemia, with over 2 million cases projected in 2023.

red blood cell

Ultra Running Accelerates Red Blood Cell Ageing

Multi omics analysis shows ultra running drives inflammatory and oxidative red blood cell damage, impairing deformability and accelerating ageing.

B12

Scientists Find Lab Test Can Explain High Vitamin B12

Macro B12 may explain persistently raised vitamin B12 levels and help avoid unnecessary bone marrow biopsy in patients with low suspicion of malignancy.

Meta Analysis Compares CAR T Constructs

Meta Analysis Compares CAR-T Constructs

Across 40 trials, 4 1BB based CAR T therapy targeting CD19 delivered the strongest remission rates and lower neurotoxicity in relapsed B cell precursor acute lymphoblastic leukaemia.

Hepta Refractory Multiple Myeloma Shows Genomic Complexity

Hepta refractory multiple myeloma is characterised by antigen loss, complex genomic alterations, and poor survival, with limited benefit from successive salvage therapies.

lymphoma

Repeat R CHOP Improves Late Relapse Lymphoma Outcomes

A second course of R CHOP achieved durable responses in late relapse diffuse large B cell lymphoma, especially in patients relapsing more than 5 years after diagnosis.

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