Hematology

New findings reveal that B cell acute lymphoblastic leukaemia depends on intact beta catenin degradation, highlighting glycogen synthase kinase 3 beta inhibition as a potential therapeutic strategy.

A large paediatric cohort study shows that platelet processing and donor factors influence posttransfusion platelet increments and transfusion burden, without affecting hospital length of stay or mortality.

Parvovirus B19 was shown to infect haematopoietic stem cells, impairing self renewal and differentiation, with JAK2 STAT5 inhibition partially reversing virus induced bone marrow dysfunction.

Dasatinib plus blinatumomab demonstrated greater and sustained immune activation than ponatinib combinations in Ph+ acute lymphoblastic leukaemia, with marked effects on lymphocytes and natural killer cells.

Early haematopoietic stem cell transplantation after liver transplantation resulted in 90% survival in children with hepatitis-associated aplastic anaemia, with normal blood counts and liver function at follow up.

Hetrombopag achieved an overall response in over three quarters of paediatric patients with immune thrombocytopenia, with durable responses and no serious adverse events reported.

RBC immunization affects over 14% of transfused patients with myelodysplastic syndromes and is independently associated with markedly reduced survival, highlighting its emerging prognostic relevance.

The ESCORT-HU and ESCORT-HU Extension studies followed 3,145 patients, with 1412 (45%) men and 1733 (55%) women….