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Diagnosis of progressive familial intrahepatic cholestasis in adulthood
6
Mins
September 2024
Progressive familial intrahepatic cholestasis (PFIC) is a cholestatic condition that typically arises in childhood. As such, if an adult…
Read more
29th December 2013
Management of Hepatitis B Virus Infection in Liver Transplant Recipients
Hepatitis B virus (HBV)-related liver disease is a common indication for liver transplantation (LT) in Asian countries. When left untreated, the overall…
29th December 2013
IL28B Polymorphisms in Interferon-Treated Patients with Chronic Hepatitis B
Pegylated interferon (Peg-IFN) may achieve a sustained off-treatment response in 20-30% of the patients with chronic hepatitis B (CHB).
29th December 2013
Cellular Consequences of Z Alpha-1 Antitrypsin Accumulation and Prospects for Therapy
The Z variant (Glu342Lys) of α1-antitrypsin polymerises and accumulates in the hepatocyte endoplasmic reticulum predisposing to neonatal hepatitis…
29th December 2013
Acute-On-Chronic Liver Failure: Applying the PIRO Concept
Acute-on-chronic liver failure (ACLF), a clinical syndrome associated with a dismal prognosis, occurs acutely in previously stable cirrhotic patients.
29th December 2013
Adrenal Insufficiency (AI) in Cirrhosis
Adrenal dysfunction or insufficiency (AI) in cirrhosis, also described as hepato-adrenal syndrome, is an only recently recognised entity.
29th December 2013
Hepatic Encephalopathy: A Paradigm Shift
The most recent understanding of the pathogenesis of hepatic encephalopathy (HE) is that heterogeneous precipitating factors cause a low-grade cerebral…
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