Hepatology

Silencing S100A11 protects against steatosis, inflammation and fibrosis in murine MASH, uncovering HK2 as a key metabolic driver and potential therapeutic target.

High-dose aluminum adjuvant Imject Alum induces immune-mediated liver inflammation and fibrosis in mice, offering a new preclinical model that mirrors human cirrhosis biology.

A new review finds statins remain safe and effective in MASLD, while evidence for PCSK9 inhibitors is promising but still limited.

Chinese surgeons have performed the first living pig-to-human liver xenotransplant, showing that a gene-edited porcine liver can support human function for weeks.

A major review suggests coffee’s bioactive compounds may help lower liver cancer risk, though benefits vary by intake, preparation method and individual lifestyle factors.

A new study suggests that the cholesterol-regulating protein PCSK9 may serve as a sensitive early biomarker for autoimmune liver diseases, helping identify patients even when routine liver tests appear normal.

New research shows that blood types A and B are linked to a higher risk of autoimmune liver disease.

Many people with primary biliary cholangitis are not receiving recommended alkaline phosphatase monitoring, and adherence is markedly higher among those under specialist care.