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Fetal Liver

Fetal Liver Organoids Recreate Human Immune–Liver Co-Development In Vitro

December 2025

By reconstructing a fetal liver–specific niche, FLOs enable simultaneous development of hepatic and hematopoietic lineages, revealing cross-talk essential for understanding human liver development and immune injury.

Fetal Liver

Fetal Liver Organoids Recreate Human Immune–Liver Co-Development In Vitro

By reconstructing a fetal liver–specific niche, FLOs enable simultaneous development of hepatic and hematopoietic lineages, revealing cross-talk essential for understanding human liver development and immune injury.

AI ECG Screening Improves Liver Cirrhosis Detection - EMJ

AI-Based ECG Screening Boosts Liver Cirrhosis Detection

AI-enhanced ECG screening uncovers silent liver cirrhosis, enabling earlier diagnosis and intervention in routine primary care.

Recurrence Pattern Predicts Outcomes After Curative Resection for Hepatocellular Carcinoma

A long-term study shows that recurrence beyond the Milan criteria, rather than recurrence itself, drives poorer survival after curative hepatocellular carcinoma resection.

Nomogram Predicts Long-Term Liver Cancer Risk After Hepatitis C Cure

Study shows DAAs and interferon offer similar long-term protection against hepatocellular carcinoma after hepatitis C cure and introduces a nomogram to predict 8-year HCC risk.

Elafibranor Shows Promise for Primary Sclerosing Cholangitis

Phase II ELMWOOD trial shows elafibranor is well tolerated and improves liver biochemistry and pruritus in primary sclerosing cholangitis, supporting further trials.

Tinengotinib Shows Promise in FGFR-Altered Cholangiocarcinoma - EMJ

Tinengotinib Shows Activity in Previously Treated FGFR-Altered Cholangiocarcinoma

A phase 2 trial finds tinengotinib demonstrates anti-tumour activity in previously treated advanced cholangiocarcinoma with FGFR alterations.

Rifaximin Use Linked to Higher Antimicrobial Resistance - EMJ

Rifaximin Use in Cirrhosis Linked to Increased Antimicrobial Resistance

A new multinational study reports that rifaximin use in cirrhosis and hepatic encephalopathy is linked to significantly higher risks of antimicrobial resistance and severe infections.

PBC

Current Liver Stiffness Best Predicts PBC Outcomes

Large PBC cohort shows current liver stiffness measurement >10 kPa predicts hepatic decompensation, outperforming biochemical response or LSM trajectory.

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