Respiratory

Dupilumab is being introduced across the NHS for eligible COPD patients, offering targeted treatment shown to reduce exacerbations by up to 34%.

Two Phase III trials involving 1,750 COPD patients found that IL-33 inhibition reduced moderate-to-severe exacerbation rates by 29–34% over 52 weeks.

A multicentre study linked greater hypoxic burden to increased systemic inflammation and reduced respiratory muscle strength in patients with obstructive sleep apnoea.

A study of 653 patients links higher vitamin A levels to slower FEV1 decline in LAM, while cell experiments highlight complex retinoid effects.

Review highlights frailty and physiological reserve in lung surgery assessment.

Two neonatal intubation depth methods showed comparable accuracy and safety, with a modified formula achieving 61% optimal tube placement.

Machine learning identified four asthma phenotypes in Korean adults, revealing differences in lung function, smoking, allergies, and nutritional factors.

A nine-year study linked elevated blood lipid index levels to earlier chronic lung disease onset, highlighting a nonlinear relationship with respiratory risk.