Respiratory

Tozorakimab shows potential benefit in patients with COPD with frequent exacerbations, despite primary endpoint not being met in overall population.

Macrophages in COPD lungs show elevated carbon loads, larger cell size, and enhanced inflammation, highlighting a potential driver of disease progression.

Paediatric-onset bronchiectasis leads to more severe disease than adult-onset, highlighting need for early, tailored care.

MiDAS, a new clinical tool, predicts poor outcomes in difficult asthma by scoring multimorbidity burden, highlighting the need for whole-patient care.

A post hoc analysis confirms dupilumab reduces key inflammatory biomarkers and COPD exacerbations, with highest benefit in patients with raised eosinophils and FeNO.

A major European study finds that exposure to multiple urban environmental factors, including air pollution and lack of green space, is significantly linked to asthma risk from childhood to adulthood.

A 14-gene test helps identify patients with early-stage non-small-cell lung cancer who benefit from chemotherapy, significantly improving 24-month disease-free survival.

The serotonin receptor gene HTR1F was linked to increased risk of sleep apnoea in non-obese adults.