Respiratory

Tozorakimab shows potential benefit in patients with COPD with frequent exacerbations, despite primary endpoint not being met in overall population.

Macrophages in COPD lungs show elevated carbon loads, larger cell size, and enhanced inflammation, highlighting a potential driver of disease progression.

Paediatric-onset bronchiectasis leads to more severe disease than adult-onset, highlighting need for early, tailored care.

MiDAS, a new clinical tool, predicts poor outcomes in difficult asthma by scoring multimorbidity burden, highlighting the need for whole-patient care.

A post hoc analysis confirms dupilumab reduces key inflammatory biomarkers and COPD exacerbations, with highest benefit in patients with raised eosinophils and FeNO.

A major European study finds that exposure to multiple urban environmental factors, including air pollution and lack of green space, is significantly linked to asthma risk from childhood to adulthood.

A 14-gene test helps identify patients with early-stage non-small-cell lung cancer who benefit from chemotherapy, significantly improving 24-month disease-free survival.

The serotonin receptor gene HTR1F was linked to increased risk of sleep apnoea in non-obese adults.

CHEST guideline updates support minimally invasive resection and targeted therapy to enhance survival in Stage I–II NSCLC.

Dupilumab was associated with increased lymphoma risk but lower overall mortality in a large asthma cohort study.

A new international trial has investigated the safety and efficacy of tailoring antibiotic treatment for cystic fibrosis exacerbations based on sputum microbiome analysis.

A genome-wide association study reveals four novel loci linked to primary spontaneous pneumothorax, identifying CBX7-mediated matrix dysregulation as a key pathogenic mechanism.

Air pollution and poverty accelerate ageing and worsen survival in fibrotic lung disease patients, new international epigenetic study reveals.

New global registry study reveals stark regional differences in diagnosis, treatment, and care quality for children with bronchiectasis.

New research links TP53, BRCA2, and ALKBH2 mutations to early-onset lung cancer in Asian women who have never smoked.

Early evidence shows that nirsevimab substantially reduced emergency bronchiolitis cases and hospital admissions in infants under 6 months.

A large Phase III trial has found that onradivir, a novel PB2 polymerase inhibitor, significantly shortens recovery time in adults with uncomplicated influenza A.

A structured parenting programme based on acceptance and commitment therapy has shown clinical benefits in managing asthma and ADHD symptoms in children.

New findings support the integration of PET/CT prior to biopsy in patients with intermediate-to-high-risk lung nodules.

A major international trial has assessed whether nasal high-flow oxygen improves outcomes during emergency paediatric intubation.

Next-generation metagenomic sequencing has uncovered key differences in bronchiectasis pathogens and resistance genes across Europe.

Machine learning models using data from digital inhalers can successfully predict COPD exacerbations up to 5 days in advance.

New research suggests that early impairment in mucosal IgA immunity may contribute to the later development of bronchiolitis obliterans syndrome in lung transplant recipients.

Gait parameters in people with COPD progressively worsen with disease severity and differ significantly from healthy older adults.