Respiratory

A post hoc analysis confirms dupilumab reduces key inflammatory biomarkers and COPD exacerbations, with highest benefit in patients with raised eosinophils and FeNO.

A major European study finds that exposure to multiple urban environmental factors, including air pollution and lack of green space, is significantly linked to asthma risk from childhood to adulthood.

A 14-gene test helps identify patients with early-stage non-small-cell lung cancer who benefit from chemotherapy, significantly improving 24-month disease-free survival.

The serotonin receptor gene HTR1F was linked to increased risk of sleep apnoea in non-obese adults.

CHEST guideline updates support minimally invasive resection and targeted therapy to enhance survival in Stage I–II NSCLC.

Dupilumab was associated with increased lymphoma risk but lower overall mortality in a large asthma cohort study.

A new international trial has investigated the safety and efficacy of tailoring antibiotic treatment for cystic fibrosis exacerbations based on sputum microbiome analysis.

A genome-wide association study reveals four novel loci linked to primary spontaneous pneumothorax, identifying CBX7-mediated matrix dysregulation as a key pathogenic mechanism.