Rheumatology

Researchers reported significant dose-dependent improvements in lupus skin disease activity with the oral TLR7/8 inhibitor enpatoran.

Systemic lupus erythematosus was associated with lower second delivery rates and recurrent pregnancy complications in a nationwide study.

Long-term tofacitinib treatment in juvenile idiopathic arthritis was associated with normal growth and stable hormone biomarkers.

Researchers have found that IL-17 inhibitors are associated with lower psoriatic arthritis risk after biologic switching in psoriasis.

Low-dose glucocorticoid treatment caused modest lumbar spine bone loss in rheumatoid arthritis over two years, a meta-analysis finds.

Researchers found higher rates of postpartum flare in rheumatoid arthritis, compared to stable disease activity in spondyloarthritis patients.

Researchers have identified sex-specific genetic risk factors in systemic sclerosis, revealing new pathways and potential treatment targets.

Large phase 3 trial involving over 300 patients with active lupus, those treated with obinutuzumab achieved markedly higher response rates at one year. Nearly 77% of patients receiving the therapy met the primary endpoint

Large cohort study finds increased cognitive impairment risk in rheumatoid arthritis, supporting routine cognitive screening in clinical care.

Discover how gut microbiota alterations may drive lupus progression, influence immune responses, and shape treatment outcomes in autoimmune disease.

Behavioural incentives increase daily steps in knee osteoarthritis, but neither incentives nor corticosteroid injections improve symptoms in clinical trial findings.

Low-dose aspirin reduces cardiovascular risk in giant cell arteritis but increases bleeding risk, highlighting a complex clinical trade-off.

Research presented at WCO suggests routine X-rays could rival DXA for osteoporosis risk assessment.

Research presented at WCO suggests men are referred too late for osteoporosis screening, with significantly lower survival after first DXA scans.

Research presented at WCO suggests hyaluronic acid injections provide modest but consistent pain relief in knee osteoarthritis, with strong safety profiles.

Research presented at WCO reveals an AI system using chest X-rays can accurately detect low bone mineral density, enabling scalable osteoporosis screening.

Study highlights fatigue as a key, measurable component of disease burden and treatment response.

A study finds metabolomic signatures linked to healthy diets may reduce knee osteoarthritis risk, with BMI mediating much of the association.

GLP-1 receptor agonists may reduce cardiovascular risk in autoimmune rheumatic diseases, offering new hope for patients and clinicians.

Trial shows clinical and molecular biomarkers can predict flare risk in rheumatoid arthritis during biologic tapering, supporting personalised treatment strategies.

An MRI-based cohort study shows HLA-B27–positive axial spondyloarthritis is linked to higher inflammation and distinct clinical features, with similar treatment use across groups.

A cross-sectional study finds nearly 80% of women with Sjögren’s syndrome experience sexual dysfunction, underscoring the need for routine assessment and support.

Trial finds diacerein does not improve knee pain in osteoarthritis patients with inflammation, questioning its clinical use.

A UK retrospective analysis finds that baseline lung comorbidities, measured using a rheumatic disease–specific index, are linked to interstitial lung disease risk in rheumatoid arthritis.

A multicentre trial will assess whether a nurse led self management intervention improves skills and quality of life in adults with newly diagnosed inflammatory arthritis.

A phase 2 trial found vunakizumab improved ACR20 response rates in active psoriatic arthritis, with sustained benefits and a favourable safety profile.

Data from the LIHOA cohort show that ultrasound-detected synovitis and synovial thickening in hand osteoarthritis are associated with worse hand function but not pain intensity.

Cast immobilisation proved non-inferior to surgery for the treatment of unimalleolar Weber B ankle fractures with a congruent mortise on initial radiography but deemed unstable by external rotation stress testing.

A case series published in BMC Rheumatology describes new-onset inflammatory arthritis following bariatric surgery, with MRI-confirmed axial and peripheral disease requiring advanced treatment.

Real-world data from TriNetX show patients with rheumatoid arthritis have a significantly increased risk of thyroid cancer, highlighting the need for awareness and surveillance.

A randomized controlled trial shows high-intensity interval and strength exercise improves multidimensional fatigue and quality of life in people with rheumatoid arthritis, with benefits lasting 12 months.

A first clinical study suggests allogeneic CD19-targeted CAR-T cell therapy can safely induce durable remission in patients with severe, treatment-refractory systemic lupus erythematosus.

UK Biobank data show people with rheumatoid arthritis have higher risks of heart disease, heart failure, and arrhythmias, with genetic analyses supporting causal links.

A first-in-human pilot trial suggests umbilical cord–derived mesenchymal stem cell eye drops may safely improve symptoms and inflammation in refractory dry eye, including Sjögren’s syndrome.

Randomised trial shows chiropractic care alters stress, immune, and neuroplasticity biomarkers in adults with spinal pain.

New data show hip osteoarthritis does not raise the risk of immune checkpoint inhibitor–induced inflammatory arthritis, while ICI-related arthritis is linked to improved survival.

Evidence from a clinical trial and long-term cohort studies suggests metformin, widely used in diabetes, may reduce knee osteoarthritis pain and lower future osteoarthritis risk.

A national cohort study shows rheumatoid arthritis remission rates in England and Wales have plateaued since 2018, with wide regional variation and delays before specialist referral limiting progress

A target trial emulation study finds no relapse reduction with cyclophosphamide added to glucocorticoids in eosinophilic granulomatosis with polyangiitis without poor-prognosis factors.

A qualitative study reveals how trust, communication, and clear responsibility between doctors influence vaccination uptake in patients with inflammatory rheumatic and musculoskeletal diseases.