Rheumatology

A first-in-human pilot trial suggests umbilical cord–derived mesenchymal stem cell eye drops may safely improve symptoms and inflammation in refractory dry eye, including Sjögren’s syndrome.

Randomised trial shows chiropractic care alters stress, immune, and neuroplasticity biomarkers in adults with spinal pain.

New data show hip osteoarthritis does not raise the risk of immune checkpoint inhibitor–induced inflammatory arthritis, while ICI-related arthritis is linked to improved survival.

Evidence from a clinical trial and long-term cohort studies suggests metformin, widely used in diabetes, may reduce knee osteoarthritis pain and lower future osteoarthritis risk.

A national cohort study shows rheumatoid arthritis remission rates in England and Wales have plateaued since 2018, with wide regional variation and delays before specialist referral limiting progress

A target trial emulation study finds no relapse reduction with cyclophosphamide added to glucocorticoids in eosinophilic granulomatosis with polyangiitis without poor-prognosis factors.

A qualitative study reveals how trust, communication, and clear responsibility between doctors influence vaccination uptake in patients with inflammatory rheumatic and musculoskeletal diseases.

New data identify age, anti-β2GP1 antibodies, and low C3 as key risk factors for cerebral small vessel disease in systemic lupus erythematosus, highlighting the need for targeted screening and risk stratification.