Urology

A nationwide cohort study found that longer denosumab treatment was associated with increased osteonecrosis of the jaw risk but no additional reduction in skeletal events beyond 12 months.

Treatment-emergent skin toxic effects during first-line enfortumab vedotin plus pembrolizumab were associated with longer overall survival.

Researchers developed an oxidative stress-based model to predict biochemical recurrence in prostate cancer and identified LAMP5 as a candidate prognostic biomarker.

A single-centre study found that elevated prostate-specific antigen density and perineural invasion were independently associated with Gleason score upgrading after radical prostatectomy in men initially diagnosed with Gleason 6 prostate cancer.

ERBB2-positive bladder cancer showed a 73.1% complete response rate with combination therapy in a phase II trial.

A global registry of 805 patients found transurethral bladder stone surgery was the most common approach, offering high stone clearance and shorter hospital stays, while other techniques were reserved for more complex cases.

A study of 221 male childhood cancer survivors linked pubertal hormone levels with adult fertility outcomes, highlighting persistent impairment after radiotherapy and evidence of hormonal recovery after intermediate-dose chemotherapy.

A learning curve analysis found that surgeons with prior Xi experience adopted single-port robot-assisted radical prostatectomy efficiently, achieving short operative times from the earliest cases.