Recent Advances in Definitive Radiotherapy for Prostate Cancer - European Medical Journal

Recent Advances in Definitive Radiotherapy for Prostate Cancer

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*Michael Pinkawa

No potential conflict of interest.

EMJ Oncol. ;3[1]:41-48. DOI/10.33590/emjoncol/10310220.
Prostate cancer, positron emission tomography, magnetic resonance imaging, external-beam radiotherapy, intensity-modulated radiotherapy, image-guided radiotherapy, simultaneous integrated boost, hypofractionation, dose escalation.

Each article is made available under the terms of the Creative Commons Attribution-Non Commercial 4.0 License.


Definitive radiation therapy is a well-recognised curative treatment option for localised prostate cancer. A suitable technique, dose, target volume, and the option of a combination with androgen deprivation therapy needs to be considered. An optimal standard external beam radiotherapy includes currently the intensity-modulated and image-guided radiotherapy techniques with total doses of ≥76-78 Gy in conventional fractionation. Data from several randomised studies increasingly support the rationale for hypofractionated radiotherapy. A simultaneous integrated boost with dose escalation focused on a computed tomography/positron emission tomography or magnetic resonance imaging/magnetic resonance spectroscopy detected malignant lesion is an option to increase tumour control with potentially no additional toxicity. The application of a spacer is a promising concept for optimal protection of the rectal wall.

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