Frequent Exacerbators in Chronic Obstructive Pulmonary Disease: From Research to Clinical Practice - European Medical Journal

Frequent Exacerbators in Chronic Obstructive Pulmonary Disease: From Research to Clinical Practice

Respiratory
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Authors:
Richard Hewitt,1 *Patrick Mallia2
Disclosure:

The authors have declared no conflicts of interest.

Received:
25.11.14
Accepted:
23.02.15
Citation:
EMJ Respir. ;3[1]:29-36. DOI/10.33590/emjrespir/10314876. https://doi.org/10.33590/emjrespir/10314876.
Keywords:
Chronic obstructive pulmonary disease (COPD), exacerbations, frequent exacerbators, biomarkers

Each article is made available under the terms of the Creative Commons Attribution-Non Commercial 4.0 License.

Abstract

Acute exacerbations of chronic obstructive pulmonary disease (COPD) are major causes of morbidity and mortality and contribute to disease progression. The frequency with which COPD patients experience exacerbations can differ markedly between patients, even those with a similar severity of airflow obstruction. This has led to the concept of ‘frequent exacerbators’ that represent a unique phenotype of COPD patients who experience frequent exacerbations and have poorer outcomes compared with patients with infrequent exacerbations. However, the mechanisms whereby some COPD patients experience frequent exacerbations remain undetermined. Understanding the mechanisms of frequent exacerbations will lead to the development of new therapies that can be targeted to these high-risk patients, thereby reducing exacerbations and improving outcomes.

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