The Importance of the mTOR Regulatory Network in Chondrocyte Biology and Osteoarthritis - European Medical Journal

The Importance of the mTOR Regulatory Network in Chondrocyte Biology and Osteoarthritis

Download PDF
*Elena V. Tchetina

The author has no conflict of interest.

EMJ Rheumatol. ;1[1]:84-95. DOI/10.33590/emjrheumatol/10311971.
Mammalian target of rapamycin (mTOR), osteoarthritis, articular cartilage, peripheral blood, nutrient signalling pathways.

Each article is made available under the terms of the Creative Commons Attribution-Non Commercial 4.0 License.


Osteoarthritis (OA) is a chronic disorder associated mainly with pain, limited range of motion, stiffness, joint inflammation, and articular cartilage (AC) destruction. Recent studies demonstrated the involvement of chondrocyte differentiation (hypertrophy) as one of the mechanisms of cartilage degradation in OA. This indicates the involvement of profound alterations in chondrocyte metabolism in the course of cartilage resorption orchestrated by principal changes in the regulation of cellular function. Mammalian target of rapamycin (mTOR) controls critical cellular processes such as growth, proliferation, and protein synthesis, and integrates extracellular signals from growth factors and hormones with amino acid availability and intracellular energy status. The importance of mTOR activity during AC destruction in OA is supported by considerable alterations in the mTOR regulatory network, involving multiple intracellular (availability of growth factors, adenosine triphosphate [ATP], and oxygen as well as autophagy) and extracellular (glucose, amino acid, lipid, and hexosamine) signals. Moreover, variable mTOR gene expression in the peripheral blood of OA patients is associated with increases in pain or synovitis, and indicates a profound metabolic dissimilarity among patients that might require differential approaches to treatment. These issues are discussed in the present review article.

Please view the full content in the pdf above.

Please rate the quality of this content

As you found this content interesting...

Follow us on social media!

We are sorry that this content was not interesting for you!

Let us improve this content!

Tell us how we can improve this content?

Keep your finger on the pulse

Join Now

Elevating the Quality of Healthcare Globally