Update on Genetic Susceptibility and Pathogenesis in Juvenile Idiopathic Arthritis - European Medical Journal

Update on Genetic Susceptibility and Pathogenesis in Juvenile Idiopathic Arthritis

Rheumatology
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Authors:
Morten Herlin,1,2 Michael B. Petersen,,1,2 *Troels Herlin3
Disclosure:

No potential conflict of interest.

Received:
04.04.14
Accepted:
26.05.14
Citation
EMJ Rheumatol. ;1[1]:73-83.

Each article is made available under the terms of the Creative Commons Attribution-Non Commercial 4.0 License.

Abstract

Juvenile idiopathic arthritis (JIA) is a multifactorial disease with a pathogenesis which remains inexplicable. However, genome-wide association studies brought forward within recent years have discovered several new susceptibility genes, and accumulating evidence supports genetic variability as playing a key role in JIA development. This review summarises the present knowledge of human leukocyte antigen (HLA) and non-HLA polymorphisms conferring disease susceptibility, and discusses the areas in JIA genetics, which are still to be investigated in order to apply JIA genetics in a clinical setting.

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