Gastroenterology

Discover a study showing how microplastics alter the gut microbiome, with changes linked to digestion, depression, and colorectal cancer risk.

A real-world study finds upadacitinib induces remission and mucosal healing in biologic-refractory Crohn’s disease patients, confirming its effectiveness and safety.

A large UK Biobank study has found that exposure to hard water is associated with reduced prevalence of Crohn’s disease and ulcerative colitis.

Discover a study revealing how insomnia raises the risk of GERD and IBS, with genetic evidence linking poor sleep to gastrointestinal health.

A UK Biobank study finds abdominal fat significantly raises GERD risk, with stronger associations in women than men.

A study from Cairo University Hospital reveals that gastric scintigraphy and the Gastroparesis Cardinal Symptom Index are valuable tools for diagnosing diabetic gastroparesis and predicting treatment outcomes.

Mesenteric fat proliferation on MRI scans is linked to higher risks of hospitalization and surgery in Crohn’s disease, suggesting a new imaging marker for long-term outcomes.

A study of over 235,000 colonoscopies found that people aged 45–49 had similar polyp and carcinoma detection rates as those aged 50–54, supporting earlier colorectal cancer screening.

Learn how GLP-1 RAs may cut peptic ulcer risk in diabetes patients by nearly half.

Uncovered self-expanding metal stents (SEMS) and balloon dilation are safe and effective treatments for benign gastric outlet obstruction; however, SEMS should not be the first choice due to its associated cost and complications.

People with gastrointestinal disorders face a higher risk of sleep problems, including insomnia and shorter sleep duration, according to a large U.S. study.

A new study finds that PD-1 inhibitors combined with chemotherapy achieved a 97.7% disease control rate and median progression-free survival of 13.5 months in advanced gastric cancer patients.

A study finds that elevated trimethylamine N-oxide (TMAO) levels are linked to increased risk of abdominal aortic aneurysm development, faster aneurysm growth, and higher likelihood of surgical intervention.

A study of nearly 300 women with obstructive defecation syndrome found that combining transperineal ultrasound with anorectal manometry offers a clearer picture of pelvic floor structure and function.

A large safety analysis of infliximab and adalimumab in pediatric inflammatory bowel disease highlights the need for continued postmarketing monitoring, with new concerns emerging for long-term infliximab use.

A Vietnamese retrospective study challenges the push for endoscopy within 12 hours in patients with esophageal variceal bleeding.

A new study demonstrates that fecal calprotectin levels, measured using fluorescent immunochromatography assay (FICA), strongly correlate with disease activity in ulcerative colitis, offering non-invasive thresholds to better guide patient care.

New research suggests that PRO-C16, a blood-based marker of type XVI collagen formation, may help detect intestinal fibrosis in patients with Crohn’s disease.

A large Iranian study has found no significant association between gastroesophageal reflux disease (GERD) and higher tooth decay rates.

New research reveals that a high-fat diet can boost levels of the gut bacterium Bacteroides thetaiotaomicron, which in turn produces palmitic acid—a fatty acid that enhances blood clotting and cardiovascular risk.

A study of AI-guided infection prevention in hospitals found no drop in C. difficile rates but did see reduced use of risky antibiotics, especially in high-risk patients.

New data from China shows vedolizumab delivers comparable long-term outcomes and safety in elderly and younger patients with moderate-to-severe ulcerative colitis.

New research shows IBS patients suffer higher depression and worse sexual health compared to healthy individuals, highlighting the condition’s broad impact on wellbeing.

A new in vitro study reveals sex-specific differences in the digestion of milk and oat-based drinks, offering important insights for personalized nutrition and food innovation.

Patients with functional anorectal pain show abnormal anal pressures, rectal hypersensitivity, and high rates of anxiety and depression, new study reveals.

A new study highlights the clinical promise of AI-driven IHC prediction models, showing high accuracy and diagnostic concordance with conventional pathology.

A new study found that the timing of small-bowel capsule endoscopy does not significantly affect detection rates of bleeding sources.

A prospective study has found that the Mediterranean diet may help reduce inflammation and support a healthier gut microbiome in newly diagnosed Crohn’s disease patients.

In patients with achalasia, esophageal Candida infection may be more than an incidental finding. A new study reveals it significantly increases the risk of developing esophageal cancer.

A large randomized clinical trial suggests that adults with uncomplicated appendicitis can safely wait for surgery without receiving antibiotics.

A study has found that H. pylori infection in gastric cancer is linked to reduced tumour-infiltrating lymphocytes and poorer patient outcomes.

Combining gelatin sponge with NBCA glue proved most effective in stopping arterial gastrointestinal bleeding, significantly outperforming sponge alone or with microcoils.

A Vietnamese study finds that a new mean nocturnal baseline impedance threshold of 1500 Ohms improves diagnostic precision for acid reflux disease.

Read about how mirikizumab shows strong results for IBD, improving remission and response rates.

Results from the phase 3 QUASAR trials show that guselkumab offers effective and safe induction and maintenance therapy for moderate-to-severe ulcerative colitis, with nearly 50% of patients achieving clinical remission after one year.

Pregnant individuals with IBD prescribed low-dose aspirin were no more likely to experience flares than those not on aspirin, according to a new study, easing concerns about its use in this high-risk population.

A new analysis from nearly 20,000 participants in the U.S. NHANES study has identified the platelet-to-high-density lipoprotein ratio (PHR) as a strong predictor of gastrointestinal cancer risk.

Tirzepatide linked to more GI issues than semaglutide in new study on weight-loss drugs without diabetes. Read more!

While both bariatric surgeries aid weight loss and quality of life, Roux-en-Y gastric bypass shows greater benefits for reducing acid reflux and oesophageal inflammation.

Research shows that compounds produced during cabbage fermentation protect gut lining from cytokine damage, highlighting the potential of fermented foods in gut health.

A new umbrella meta-analysis finds strong evidence that probiotics, particularly multi-strain formulations, reduce the risk of necrotising enterocolitis (NEC) and death in preterm babies.

New data from Ontario reveals a concerning rise in alcohol-related gastrointestinal diseases among people aged 13 to 39, with young women showing the steepest increase.

Researchers report that a novel cap-assisted clip closure technique shortens procedure time without compromising safety in patients undergoing endoscopic tumour resection.

New research suggests matcha may offer greater protection than green tea against intestinal injury caused by gamma radiation, via the TAK1–TAB pathway.

A new study links high glycemic index and load diets with increased risk of pancreatic steatosis, while fibre intake appears protective.

A new mobile app is helping doctors adhere to colorectal cancer screening guidelines, reducing unnecessary colonoscopies while identifying high-risk patients needing intensive follow-up.

A large international study shows that intestinal ultrasound during pregnancy can reveal hidden inflammatory bowel disease activity, significantly improving prediction of complications like preterm birth and preeclampsia, beyond what clinical symptoms and lab tests can detect.

New findings from a decades-long study of over 470,000 adults show that higher calcium intake may significantly reduce the risk of colorectal cancer, regardless of whether it comes from dairy, non-dairy foods, or supplements.