FLT3 Mutations in Patients with Acute Myeloid Leukaemia: The Importance of Identification and Monitoring for Prognostic Determination and the Selection of Optimal Treatment Strategies
Mutations in FLT3 are the most common genetic alteration in AML. Patients with a FLT3 internal tandem duplication (ITD) mutation subtype have poor prognosis, especially when there is a high allelic burden.