Hepatology

Interestingly, liver transplant recipients did not experience excess mortality, likely due to restored liver function post-transplant.

Discover a study highlighting how small-incision large-expansion improves PAD treatment outcomes, offering safer, faster stone removal and preserved sphincter function.

This investigation examined 72 patients with hepatitis virus infection or alcohol-related liver disease across various stages, providing a detailed picture of immune changes in cirrhosis.

For individuals with MASLD and Type 2 diabetes, these findings suggest that tirzepatide and semaglutide could play a significant role in reducing liver-related complications

Crucially, these trends were observed for overall survival as well and were successfully reproduced in the separate validation set.

Traditionally, most European and Spanish guidelines recommend viral hepatitis screening only in individuals with recognised risk factors or elevated liver enzyme levels.

Discover a study showing how HCV eradication with antivirals during immunotherapy improves survival, liver function, and treatment outcomes in advanced hepatocellular carcinoma.

Recent research has investigated whether low-molecular-weight fucoidan, a compound derived from brown seaweed, could enhance the efficacy of TACE.

A new randomised controlled trial has investigated the impact of dietary fibre supplementation on patients with T2DM and MASLD.

Discover a study showing how resistance training can improve inflammation, oxidative stress, and physical performance in patients with liver cirrhosis.

A recent study has identified the multifunctional protein G3BP1 as a key regulator of lipid metabolism in the liver.

The results demonstrated a high probability, 97.3%, that shorter durations of antibiotic prophylaxis, including no treatment, were noninferior to longer durations for all-cause mortality.

Discover a study showing that post-treatment AFP levels help predict hepatocellular carcinoma risk in chronic hepatitis C patients after antiviral therapy.

Potential mechanisms behind BSV’s protective effect may mirror those described for tenofovir-based therapies, such as modulation of inflammatory and oncogenic pathways.

Emerging evidence points to the role of CD4+ T cell subsets in fuelling MAFLD-related inflammation and fibrosis.

Learn how new research links major air pollutants with increased NAFLD risk, urging broader public health focus.

Understand how paternal hepatitis B has no significant effect on ART pregnancy or live birth outcomes.

Combined liver transplant and sleeve gastrectomy yield lasting weight loss and fewer metabolic complications in patients with obesity.

The team concluded that CLD remains a major health burden in Thailand, highlighting the need for strong prevention strategies, early diagnosis, and equitable access to effective therapies.

Discover a study exploring how verbal instructions and symptom expectations influence fatigue and motivation in people living with primary biliary cholangitis.

The findings suggest that a multi-marker, multi-pathway approach can account for the heterogeneous ways HCC emerges.

This nationwide South Korean cohort study examined over six million young adults aged 20–39 years to assess new-onset AF according to contemporary SLD subtypes.

A case series has reported the first successful use of combined liver and haploidentical stem cell transplantation to cure patients with severe sickle cell disease (SCD) complicated by advanced liver failure.

Emerging evidence also implicates air pollution in metabolic disorders common in later life, including dyslipidaemia, weight gain and impaired glucose homeostasis.

In this randomised prospective study, 72 living liver donors scheduled for right hepatectomy were enrolled and divided into two groups.

Silymarin, vitamin E, and phospholipids combination therapy effectively reduces liver steatosis, fibrosis, and metabolic risk in MASLD.

Exc: Adults received three consecutive FMTs, either allogeneic (from healthy donors) or autologous (their own stool), with liver fat measured by MRI-derived proton density fat fraction.

Discover a study assessing whether a five-minute rapid antibody test can speed up hepatitis C diagnosis. Read on.

New findings suggest that non-targeted screening for hepatitis C virus may be more effective than targeted screening for identifying new HCV infections in the emergency department.

Ascorbic acid (AA) supplementation could potentially reduce post-reperfusion syndrome (PRS) during liver transplantation

Vitamin D boosts UDCA treatment success inpatients with PBC, improving liver function and reducing hepatic fibrosis progression.

Learn how cholecystectomy may raise the risk of MASLD, particularly in patients with obesity, diabetes, or high blood pressure. Read the full study findings.

Discover a study evaluating how intrathecal morphine improves early postoperative pain relief and reduces morphine use after open liver surgery.

If validated in larger, diverse populations, the VAS-MASH-US score could represent a major advancement in hepatology.

The study explored the anti-inflammatory and analgesic effects of low-dose ketamine and Dex, both commonly used anaesthetic agents with known immune-modulating properties.

This study focused on eGDR, a widely accessible proxy for insulin sensitivity derived from waist circumference, hypertension status, and HbA1c levels.

Key findings showed a clear, stepwise increase in risk of complications, including heart failure, stroke, and cardiac arrest, as liver fibrosis scores rose.

In patients with advanced chronic liver disease, several factors such as diet, changes in gut bacteria, and disruption of the gut–vascular barrier can lead to altered levels of TMA and TMAO.

Discover how SGLT-2 inhibitors are linked with reduced risk of serious liver events in cirrhosis patients.

The study highlights stark contrasts in ACLF triggers across regions: HBV predominates in Eastern countries such as China, while alcohol is the main culprit in the West.

Discover a study revealing how subclinical liver fibrosis, measured by FIB-4, predicts increased mortality risk in coronary artery disease patients.

While other machine learning models like MoRAL-AI and TRAIN-AI have also shown promise, TRIUMPH distinguishes itself through its robust generalisability.

While the primary outcome, a ≥10% reduction in α-SMA, was reached in 29% of ReFerm® recipients versus 14% in the control group, the difference was not statistically significant.

Using superconducting quantum interference device magnetometry, researchers examined the magnetic properties of post-mortem brainstem tissue from four individuals.

Large UK studies show no increased liver cancer risk with oral contraceptives, though longer use may slightly raise risk.

In this study, MASLD was identified in 50% of the T2DM cohort using non-invasive methods, slightly lower than some global estimates.

Discover a study exploring how gut microbiome imbalances contribute to MASLD progression and offer new diagnostic and therapeutic possibilities.

Metabolic and genetic disorders emerged as the most frequent aetiological group, reflecting broader diagnostic capabilities compared to earlier studies.

Beyond the head-to-head comparison, the study also explored innovative strategies to simplify or shorten treatment.

The study offers important insights into the therapeutic potential of short-chain fatty acids supplementation in MASLD, especially in non-obese patients.

This 12-month study explored the impact of ethanol-extracted curcumin on liver health, inflammation, and metabolic parameters in individuals with MASLD.

The biomarker identifies those at highest risk of non-adherence and helps determine how much support they receive during the intervention.

Despite the well-documented association between HBV and HCC, the exact mechanisms driving HBV-induced HCC remain largely unknown.

Biliary atresia is the most common surgical cause of cholestatic jaundice in infants and the leading reason for paediatric liver transplants

A recent prospective study explored the effectiveness of using indocyanine green to improve intraoperative detection of bile leakage.

Discover a study that found that individuals with higher baseline IL-1β levels experienced greater improvements in liver health following weight loss.

The results suggest that while MASLD is common in patients with T2DM in primary care, advanced liver disease is rare.

The findings highlight the potential for behavioural strategies, such as dietitian-led interventions, to play a key role in managing liver health.

Results showed that patients receiving the combination therapy experienced a median progression-free survival of 5.8 months, compared with 4.0 months.

This study explored the effects of various metabolic abnormalities, such as central obesity, high blood pressure, and elevated high-sensitivity C-reactive protein (hsCRP), on liver steatosis and fibrosis.

Discover more about strong evidence that public health measures, such as raising alcohol prices and restricting access can significantly reduce alcohol consumption.

Dapagliflozin shows promise for treating MASH, improving liver outcomes without worsening fibrosis in a major trial.

A 2023 global call to action by over 300 experts highlighted the need for clear, cross-specialty care pathways to support earlier identification and referral of people at risk.

In this double-blind, placebo-controlled trial, 181 participants were randomised to receive weekly injections of either 28 mg or 50 mg of efruxifermin or a placebo.

These figures indicate a substantial drop-off following diagnosis, undermining efforts to eliminate HCV in paediatric populations.

The model analyses demographic information, lab results, and other clinical data to predict the cause of graft injury across six possible conditions.

This new study highlights the growing role of extracellular volume measurement using spectral CT, which quantifies the proportion of extracellular matrix.

The findings support the concept that excessive lipogenesis, rather than just fat delivery from other sources, is central to MASLD development.

A study has revealed that pemafibrate is more effective than omega-3 fatty acid ethyl in reducing fatty liver index.

Discover a study that suggests that dual therapy could offer a safer and more effective approach to treating MASLD.

A recent study investigated how different naturally occurring fibrinogen variants relate to obesity, MASLD, and liver fibrosis severity.

PLAN-B-DF was trained and internally validated on a large cohort of 5,585 patients, and externally validated.