Interventional Cardiology

Non–procedure-related bleeding occurred in 10.9% of patients receiving left atrial appendage closure versus 19.0% of those on anticoagulants (hazard ratio: 0.55; 95% CI: 0.45–0.67; p

Notably, the HFpEF prevalence in this INOCA group reached 35.29%, meaning over one-third of patients met established diagnostic criteria.

Heart failure hospitalisation was associated with a markedly increased risk of death (adjusted hazard ratio [HR]: 6.11), far exceeding that of ACS (HR: 3.22) and major bleeding (HR: 2.62).

In patients with post-stroke disability, all-cause mortality more than doubled (HR:2.18; 95% CI:1.84–2.60; p

In the absence of cardiomyocyte TGFB3, the study observed increased expression of profibrotic mediators including connective tissue growth factor (CTGF) and SERPINE1.

Endothelial Twist1 expression promoted plaque growth but simultaneously enhanced hallmarks of plaque stability, including increased collagen deposition and a greater number of ACTA2-positive smooth muscle–like cells.

Mortality occurred in 4.5% of patients in the sheath group versus 18.2% in the non-sheath group. Neurological outcomes also favoured preprocedural vascular sheath insertion.

Transcatheter aortic valve implantation results in a higher risk of mortality and stroke compared with surgical replacement, a 2026 systematic review has found.