Nephrology

A new study identifies key predictors of successful renal replacement therapy weaning and introduces a bedside tool to guide ICU decision-making.

Greater chronic kidney disease severity, particularly proteinuria, is linked to increased risk of cognitive impairment, a large cohort study finds.

RAAS inhibitors reduce kidney failure risk and improve blood pressure control compared with calcium channel blockers in children with CKD, new real-world data show.

Interim results from the Phase III VISIONARY trial show that sibeprenlimab significantly reduced proteinuria and improved disease biomarkers in patients with IgA nephropathy.

A large UK study finds commonly used eGFR equations may overestimate kidney function, potentially delaying chronic kidney disease diagnosis and treatment.

A study suggests convection volume in haemodiafiltration may be tailored to patient weight and residual kidney function to optimise middle-molecule clearance.

A study of hospitalised patients with acute kidney injury shows that failing to recover creatinine within 10% of baseline at 3 months predicts worse 5-year kidney outcomes.

Sepsis may worsen or improve AKI survival depending on illness severity, new data suggest. Explore how risk reverses in the sickest patients. Read more.

Elevated red cell distribution width-to-platelet ratio predicts cardiac surgery-associated acute kidney injury and improves risk stratification.

Study finds high rates of cognitive impairment in haemodialysis patients, with poorer physical function seen in those with established cognitive decline.

More than half of surgical ICU patients developed postoperative acute kidney injury, with sepsis, trauma, and CKD among key risk factors.

GLP-1 receptor agonists were associated with lower dementia and Alzheimer’s risk in patients with type 2 diabetes and CKD stage 3 or later.

A nationwide cohort study finds higher rates of congenital malformations in babies born to mothers with chronic and end-stage kidney disease.

A global analysis of childhood CKD reveals rising adolescent incidence, widening health inequalities, and links between kidney replacement therapy access and reduced disease burden.

A large meta-analysis links reduced kidney function to higher Alzheimer’s disease blood biomarkers, suggesting renal health may affect interpretation of dementia tests.

A nationwide comparative study shows SGLT2 inhibitors lower long-term chronic kidney disease and acute kidney injury risk compared with GLP-1 receptor agonists.

Melatonin supplementation reduced inflammation and improved lipid profiles in children undergoing chronic haemodialysis, suggesting potential cardiovascular and antioxidant benefits.

A preliminary study suggests a plant-based low-protein diet may improve metabolic and inflammatory parameters and help prevent malnutrition–inflammation complex syndrome in adults with CKD.

Altered serum and urinary bile acids were identified in patients with advanced chronic kidney disease, with specific bile acids associated with declining kidney function.

ERA Registry data show rising kidney replacement therapy incidence and prevalence across Central and Eastern Europe, with wide national variation and limited COVID-19 impact.

Meta-analysis shows neutrophil to lymphocyte ratio is associated with higher risk and progression of diabetic nephropathy, supporting its potential use as an inflammatory biomarker in clinical practice.

In a multivariate Cox proportional hazards model, statin therapy was associated with a 52% relative reduction in the risk of death at 30 days.

39 studies involving 14 300 participants showed that patients with diabetic nephropathy had significantly elevated NLR levels compared to diabetic controls without nephropathy.

Kidney transplant recipients from socioeconomically disadvantaged neighbourhoods face important inequalities in cancer risk and outcomes…