Oncology

A multicentre study suggests selected Child-Pugh B liver cancer patients may benefit from first-line atezolizumab/bevacizumab despite poorer survival outcomes.

A nationwide analysis found a marked increase in detection of congenital lung malformations over 30 years, alongside changing disease patterns and frequent inflammatory findings in resected lesions.

Early postoperative MRI demonstrated high diagnostic accuracy for detecting residual disease after neuroblastoma surgery and may help guide treatment decisions.

Long-term data from the FASTRACK II trial suggest stereotactic ablative body radiotherapy offers durable local control and a favourable safety profile in patients with primary renal cell carcinoma who are unsuitable for surgery.

A machine learning model using urinary extracellular vesicle physical parameters demonstrated strong diagnostic performance for early prostate cancer detection.

Individualised cancer risk models revealed marked variation in lifetime and 10-year cancer risk, with healthy behaviours associated with substantial risk reduction.

Deep learning models demonstrated strong predictive performance for immunotherapy outcomes in metastatic non small cell lung cancer, outperforming radiomics approaches.

Lorlatinib achieved high response rates in patients with ALK driven neuroblastoma, though efficacy varied by molecular profile and resistance patterns emerged.