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Neurology
1 Mins
5 Aug 2025

Glymphatic Dysfunction in Motor Neurone Disease Phenotypes

Converging evidence supports a key pathogenic role of the glymphatic system in the accumulation of pathological aggregates in several…
Neurology
1 Mins
5 Aug 2025

Rapid Molecular Classification of Brain Tumours with Nanopore Sequencing

Profiling of DNA methylation, a stable epigenetic marker of cell identity, has become a significant tool in precision cancer diagnostics…
Neurology
2 Mins
5 Aug 2025

Impact of Vascular Risk Factors on Motor Performance and Sensorimotor Integrity in MS

Multiple sclerosis (MS) has been traditionally considered a chronic, immune-mediated disease of the central nervous system (CNS). However…
Neurology
1 Mins
5 Aug 2025

Brain Functional Neural Organisation of Apathy and Depression in ALS

Apathy and depression are the most prevalent neuropsychiatric symptoms in amyotrophic lateral sclerosis (ALS).1-3 Although insufficiently…
Hematology
2 Mins
24 Jul 2025

PPM1D Mutations in Patients with Clonal Haematopoiesis and Clonal Cytopenias

TP53 and PPM1D are key regulators of DNA damage response and repair, and somatic mutations in these genes often…
Hematology
1 Mins
24 Jul 2025

Hydroxyurea and Gut Function in Sickle Cell Disease Mice

Sickle cell disease (SCD) is a genetic disorder characterised by chronic inflammation, vaso-occlusion, and endothelial…
Hematology
1 Mins
24 Jul 2025

Long-Term Outcomes After Allo-HSCT in ALL

Patients (pts) with acute lymphoblastic leukaemia (ALL) in difficult first complete remission (CR) or in second CR, and…
Hematology
1 Mins
24 Jul 2025

Microfluidic Testing in Patients with BDUC

In 40–70% of patients referred to a haematologist for the evaluation of an increased bleeding tendency, no diagnosis can…
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