Bladder Cancer and Genetic Polymorphisms: A Review - European Medical Journal
×

Browse

Bladder Cancer and Genetic Polymorphisms: A Review

| Download as | PDF
Authors:
*Bulent Erol, Ismail Ulus, Yavuz Onur Danacıoglu, Turhan Çaşkurlu
Disclosure:

No potential conflict of interest.

Received:
13.10.14
Accepted:
19.11.14
Citation
EMJ Urol. ;3[1]:20-25.

Each article is made available under the terms of the Creative Commons Attribution-Non Commercial 4.0 License.

Abstract

The aetiology of bladder cancer (BC) is still not fully understood. Genetic factors and many different pathways could be involved in the formation and progression of the BC. Some investigators have reported genetic polymorphisms (GPMs) in various genes which might be associated with BC. As summarised  below, we have seen an explosion of literature reporting an association between genetic variation and BC risk, as well as between GPM and clinical outcome. In this review GPMs are categorised based on their primary cellular functions: genes in carcinogen metabolism, DNA repair, cell cycle control, inflammation, apoptosis, methylation, genes functioning as G proteins, and cell adhesion molecules. A pathway-based genotyping approach, which assesses the combined effects of a panel of polymorphisms that act in the same pathway, may amplify the effects of individual polymorphisms and should be more advantageous to association study than the candidate gene approach.

Please view the full content in the pdf above.