European Archives - Page 871 of 1343 - European Medical Journal

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Phase Ib/II Study of the IDH1-Mutant Inhibitor Ivosidenib
3 Mins
30 Jul 2020

Phase Ib/II Study of the IDH1-Mutant Inhibitor Ivosidenib, with the BCL2-Inhibitor Venetoclax +/-Azacitidine in IDH1-Mutated Myeloid Malignancies

Venetoclax is a potent, selective, oral inhibitor of B-cell lymphoma-2. It is approved in the USA in combination with azacitidine, decitabine…
hematology 8.1 featured image
2 Mins
30 Jul 2020

Mechanistic Insights into the Inhibition of Regulatory T Cells by Dasatinib in Chronic Myeloid Leukaemia Patients with Clonal Lymphocytosis

Dasatinib is a potent inhibitor of lymphocyte-specific protein tyrosine kinase (Lck), which plays a pivotal role in T-cell receptor (TCR) signalling…
hematology 8.1 featured image
6 Mins
30 Jul 2020

Pregnancy-Related Thromboembolism in Sickle Cell Disease

Haematological disorders are predominant in the tropical and subtropical countries where major problems of sickle-cell disease (SCD) and thalassaemias…
hematology 8.1 featured image
2 Mins
30 Jul 2020

Identification of HIF2α as a Novel Determinant of Acute Myeloid Leukaemia Block of Differentiation Poses its Inhibition as a Potential Therapeutic Opportunity for Acute Myeloid Leukaemia Patients

Signalling via hypoxia inducible factors (HIF)1α and HIF2α is importantly implicated in cancer,1 although it has been predominantly studied in solid…
Initial Anticoagulant Management of Deep Vein Thrombosis
8 Mins
30 Jul 2020

Anticoagulant Management of Deep Vein Thrombosis: Review of Current Approaches

The initial management of deep vein thrombosis is starting to happen in general practice.
hematology 8.1 featured image
1 Mins
30 Jul 2020

Comparison of Decitabine with Venetoclax versus Intensive Chemotherapy Using Propensity Score Matching and Treatment-related Mortality Risk Scoring

Acute myeloid leukaemia (AML) usually presents in older patients over the age of 65 years.1 A large proportion of such patients are frail or have…
hematology 8.1 featured image
6 Mins
30 Jul 2020

Concerns Regarding the Management of β-Thalassaemia Patients in the Era of COVID-19

Many cases of pneumonia clustered in the city of Wuhan, China, were reported in December 2019, and source tracing has showed Huanan Seafood Market, Wuhan, China, as the origin.
Expanding the Role of CAR-T Cell Therapy to Systemic Lupus Erythematosus
8 Mins
30 Jul 2020

Expanding the Role of CAR-T Cell Therapy to Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disorder resulting from autoantibodies produced by B-cell derived plasma cells.
Pancytopenia Secondary to Adult Osteopetrosis
4 Mins
30 Jul 2020

Pancytopenia Secondary to Adult Osteopetrosis

Osteopetrosis (OP) is a rare genetically metabolic bone disorder caused by severe impairment of osteoclast-mediated bone resorption.
Adult-Onset Still’s Disease Complicated with Haemophagocytic
5 Mins
30 Jul 2020

Adult-Onset Still’s Disease Complicated with Haemophagocytic Lymphohistiocytosis

Haemophagocytic lymphohistiocytosis (HLH) is a rare but potentially aggressive and life-threatening syndrome of overactive histiocytes and lymphocytes…
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