Allergy & Immunology

The infant gut microbiome is dynamic and responsive to early-life environmental influences, with sibling exposure emerging as a potentially important factor in shaping microbial development.

Patients who underwent DOC were significantly more likely to receive penicillin at 90 days and less likely to be prescribed World Health Organization “Watch” or “Reserve” antibiotics.

The findings showed that early immune cross-regulation played a decisive role in controlling protease hypersensitivity

Polygenic risk score models derived from variants prioritised by the deep learning framework demonstrated improved predictive performance compared with those based on traditional GWAS approaches.

In a direct comparison, the AI models outperformed 24 clinicians when diagnosing a subset of patients.

In a mouse model of allergic rhinitis, even a very low dose (0.5 ng) of bryo-1 delivered via anionic LNPs increased antigen-specific IgA levels in salivary secretions.

While treatment costs were higher – A$3956 for PPOIT and A$3582 for OIT versus A$249 for no treatment – these were offset by improved clinical outcomes.

Mechanistic studies revealed a reciprocal relationship between receptors: S1PR1 enhanced IL-13 and IL-9 production, whereas S1PR5 suppressed these cytokines.