Allergy & Immunology

Language barriers lead to worse outcomes in patients with asthma, with poorer lung function, a higher risk of uncontrolled asthma, and more emergency department visits, highlighting the need for culturally and linguistically appropriate care.

Excerpt: New research reveals that pore-forming proteins in common allergens perforate airway cells, triggering immune responses that lead to respiratory allergies. This discovery uncovers a shared mechanism behind diverse allergens and offers potential new targets for allergy treatment.

Find out more about peanut oral immunotherapy as a promising treatment for young children in Australia with peanut allergy.

These findings support the effectiveness of herbal-based emollients plus in managing atopic dermatitis, extending beyond simple hydration to actively aiding in barrier repair and symptom relief.

The BTCRC LUN 16-081 trial is the first to evaluate a shorter, six-month course of consolidation immunotherapy using nivolumab alone or in combination with ipilimumab.

The study found that patients receiving the AR-PRISE intervention experienced significant improvements in symptom control, particularly over the longer term.

The study also highlighted the diagnostic challenges posed by unreliable histories and overlapping symptoms from infection-related exanthems.

Peanut oral immunotherapy (POIT), which involves gradually increasing exposure to peanut protein, has shown promise, successfully desensitising 50–70% of patients.

A recent landmark study is the first randomised, controlled trial to show clinical benefits of an allergy app for SAR sufferers.

In a new study, researchers identified a specific immune cell type, CD4+ T follicular helper (Tfh) cells producing IL-21 and IFN-γ, as a key driver of ICI-T1DM.

Discover a study linking everyday plastic chemicals to increased risks of asthma, wheezing, and allergies in young children.

Traditionally, FA management has focused on avoidance or reducing allergenicity by altering the protein structure of allergens through heat, pressure or other treatments.

The findings provide genetic evidence supporting the theory that the nervous and immune systems may interact more closely in children with ADHD.

Researchers analysed antibiotic prescriptions for a 15-month period after discharge, comparing patients with and without penicillin allergies.

One in four U.S. infants lacks Bifidobacterium, a key gut microbe essential for immune and metabolic health.

Results showed that dupilumab improved histologic, endoscopic, and symptomatic markers of EoE across all patient groups.

Specifically, for every 10-μg/m³ increase in ambient air pollutants, there was a measurable increase in AD-related healthcare visits.

Discover how climate change is profoundly altering allergic rhinitis, extending allergy seasons, and increasing healthcare burdens and educational needs globally.

The study suggests that the inflammatory processes central to AR may also affect the brain, potentially leading to mood disturbances through mechanisms such as elevated cytokines or histamine imbalance.

The combination therapy demonstrated a significantly higher response rate (98.28%) compared to loratadine alone (87.93%).

Discover a new study that has assessed the relationship between indoor home environmental exposures and lung function in children with asthma.

Discover a study that found that children with early AD were more likely to develop food allergies, whereas those with later onset were more associated with allergic rhinitis.

Discover a study where findings suggest that previous estimates may have underrepresented the true HAE population by excluding HAE-nl-C1INH.

A study has revealed that children with atopic asthma may be at greater risk of sensory processing disorder, suggesting a deeper neurodevelopmental link.

Symptoms experienced over the past week were common and impactful, with over half of the participants reporting dysphagia and nearly half experiencing heartburn.

These findings suggest that most children can maintain tolerance to nuts even after a short period without exposure, following a structured course of N-OIT.

Conducted across 19 countries, this large-scale observational study gathered data from 1,392 patients with CSU and 1,374 healthy controls.

This study investigates the role of the intranasal Schirmer test as a supportive or alternative tool to anterior rhinomanometry for allergic rhinitis.

Discover a study that highlights the importance of identifying high-risk children through biomarkers and better understanding neutrophil function in RSV infection.

Moreover, the infant’s gut microbiota may play a role in both allergy development and tolerance.

Interestingly, the study also revealed a disconnect between clinical and biological remission.

The study highlights a potentially critical role for the BDNF-NTRK2 pathway in symptom development.

This study is especially important because existing diagnostic methods, including skin testing, have shown limited sensitivity.

The PHECDA trial evaluated stapokibart as an add-on therapy during pollen season in adults with moderate-to-severe seasonal allergic rhinitis.

Discover a study that found that 58.8% of shrimp-allergic patients also had allergic rhinitis, and 11.7% had asthma. Learn more.

Children with septic shock who received ulinastatin alongside standard therapy showed significantly improved clinical outcomes.

Excessive anxiety surrounding food allergies is common and can significantly impact a patient’s quality of life.

A novel CAR T cell therapy has shown encouraging results in children and adults with relapsed/refractory B-cell acute lymphoblastic leukaemia.

Each year, up to 138,000 people die and around 400,000 more are left permanently disabled from snakebites.

Researchers have explored the potential of intense pulsed light therapy as a supplementary treatment for refractory SAC.

The analysis demonstrated significant reductions in HAE attacks among adolescent patients.

Researchers developed a new evolutionary framework centred on immune robustness, the ability to fight infection while limiting damage.

A recent randomised clinical trial sought to determine whether high-dose aspirin remains necessary during acute-stage KD treatment.

The RILECSU phase 2 clinical trial has introduced a potential new option: rilzabrutinib.

During the immunosuppressive phase, researchers identified a marked decline in monocyte function and maturation.

Researchers have discovered a myeloid-derived APC population that is essential for generating both food- and microbiota-specific peripherally induced regulatory T cells.

The study suggests that initiating Artemisia annua SLIT during the pollen season is just as safe and well-tolerated as starting it before.

The results suggest that Wendan Decoction and acupuncture into treatment plans may enhance clinical outcomes for patients with urticaria.

A recent single-blind, randomised controlled trial evaluated the efficacy of normal saline nasal irrigation in managing allergic rhinitis symptoms.

The study found gluten-derived excipients in 44.4% of analgesics and antipyretics.

Over half of the studies identified a direct link between climate change and extended pollen seasons.

The revised mRNA-1010 formulation, evaluated in a subsequent trial, met all primary immunogenicity goals.

The study suggests that chronic inflammation caused by allergic rhinitis could contribute to carcinogenesis through oxidative stress.

Mental health concerns were prevalent, with nearly all families experiencing stress.

This study aimed to assess whether maternal exposure to LC-PCBs in indoor air during pregnancy was associated with the development of asthma.

The study also highlighted a reduction in restricted antibiotic use among patients in the intervention group compared with the control group.