Gastroenterology

A new longitudinal study finds that many adolescents with IBS struggle to manage complex treatment plans, highlighting key barriers to effective self-management.

Global research finds that gut microbiota dysbiosis strongly correlates with rising inflammatory bowel disease rates worldwide.

Chronic hepatitis C infection has been linked to a higher risk of pancreatic cancer.

New research reveals that bone broth’s amino acids and minerals can fortify the gut barrier and ease inflammation, providing scientific backing to its traditional use in digestive health.

A new study finds that sleeping with a low pillow height significantly increases the risk of throat reflux in patients with GERD, suggesting that simple lifestyle changes like elevating the head during sleep may ease symptoms.

Antithrombotic therapy does not affect polyp, adenoma, or cancer detection in FIT-positive colonoscopies after adjusting for age and sex.

A large-scale Korean study of over 115,000 adults has found that eating one to three servings of kimchi per day is linked to a lower risk of obesity and abdominal fat.

A new study finds that a staged health education pathway checklist improves discharge readiness and health literacy in esophageal cancer surgery patients.

A study of over 3,800 ICU patients finds the lactate-to-glucose ratio predicts short-term mortality in cirrhosis, offering a simple new tool for bedside risk assessment.

A Japanese multicentre study finds linked colour imaging significantly reduces missed colorectal polyps compared with standard white light imaging, improving adenoma detection rates.

A UK Biobank study finds aspirin users with multiple cardiometabolic risk factors—such as diabetes and hypertension—have nearly double the risk of GI bleeding.

A randomised trial shows 200 mg simethicone with PEG-ELS is as effective as 1200 mg for bowel cleansing and adenoma detection in afternoon colonoscopy.

A nationwide Icelandic study confirms an ICD-10 algorithm accurately identifies major GI bleeding in anticoagulated patients, improving reliability of registry-based research.

New ESSENCE trial data show semaglutide improves liver histology and non-invasive markers in MASH through mechanisms beyond weight loss, highlighting dual metabolic benefits.

New joint statement from United European Gastroenterology and the German Society for Gastroenterology calls for coordinated prevention, early detection, and policy reform to reverse the rising tide of liver cancer across Europe.

Discover a new study showing both sugary and artificially sweetened drinks raise the risk of liver disease, with water emerging as the healthiest choice.

Discover a study showing how microplastics alter the gut microbiome, with changes linked to digestion, depression, and colorectal cancer risk.

A real-world study finds upadacitinib induces remission and mucosal healing in biologic-refractory Crohn’s disease patients, confirming its effectiveness and safety.

A large UK Biobank study has found that exposure to hard water is associated with reduced prevalence of Crohn’s disease and ulcerative colitis.

Discover a study revealing how insomnia raises the risk of GERD and IBS, with genetic evidence linking poor sleep to gastrointestinal health.

A UK Biobank study finds abdominal fat significantly raises GERD risk, with stronger associations in women than men.

A study from Cairo University Hospital reveals that gastric scintigraphy and the Gastroparesis Cardinal Symptom Index are valuable tools for diagnosing diabetic gastroparesis and predicting treatment outcomes.

Mesenteric fat proliferation on MRI scans is linked to higher risks of hospitalization and surgery in Crohn’s disease, suggesting a new imaging marker for long-term outcomes.

A study of over 235,000 colonoscopies found that people aged 45–49 had similar polyp and carcinoma detection rates as those aged 50–54, supporting earlier colorectal cancer screening.

Learn how GLP-1 RAs may cut peptic ulcer risk in diabetes patients by nearly half.

Uncovered self-expanding metal stents (SEMS) and balloon dilation are safe and effective treatments for benign gastric outlet obstruction; however, SEMS should not be the first choice due to its associated cost and complications.

People with gastrointestinal disorders face a higher risk of sleep problems, including insomnia and shorter sleep duration, according to a large U.S. study.

A new study finds that PD-1 inhibitors combined with chemotherapy achieved a 97.7% disease control rate and median progression-free survival of 13.5 months in advanced gastric cancer patients.

A study finds that elevated trimethylamine N-oxide (TMAO) levels are linked to increased risk of abdominal aortic aneurysm development, faster aneurysm growth, and higher likelihood of surgical intervention.

A study of nearly 300 women with obstructive defecation syndrome found that combining transperineal ultrasound with anorectal manometry offers a clearer picture of pelvic floor structure and function.

A large safety analysis of infliximab and adalimumab in pediatric inflammatory bowel disease highlights the need for continued postmarketing monitoring, with new concerns emerging for long-term infliximab use.

A Vietnamese retrospective study challenges the push for endoscopy within 12 hours in patients with esophageal variceal bleeding.

A new study demonstrates that fecal calprotectin levels, measured using fluorescent immunochromatography assay (FICA), strongly correlate with disease activity in ulcerative colitis, offering non-invasive thresholds to better guide patient care.

New research suggests that PRO-C16, a blood-based marker of type XVI collagen formation, may help detect intestinal fibrosis in patients with Crohn’s disease.

A large Iranian study has found no significant association between gastroesophageal reflux disease (GERD) and higher tooth decay rates.

New research reveals that a high-fat diet can boost levels of the gut bacterium Bacteroides thetaiotaomicron, which in turn produces palmitic acid—a fatty acid that enhances blood clotting and cardiovascular risk.

A study of AI-guided infection prevention in hospitals found no drop in C. difficile rates but did see reduced use of risky antibiotics, especially in high-risk patients.

New data from China shows vedolizumab delivers comparable long-term outcomes and safety in elderly and younger patients with moderate-to-severe ulcerative colitis.

New research shows IBS patients suffer higher depression and worse sexual health compared to healthy individuals, highlighting the condition’s broad impact on wellbeing.

A new in vitro study reveals sex-specific differences in the digestion of milk and oat-based drinks, offering important insights for personalized nutrition and food innovation.

Patients with functional anorectal pain show abnormal anal pressures, rectal hypersensitivity, and high rates of anxiety and depression, new study reveals.

A new study highlights the clinical promise of AI-driven IHC prediction models, showing high accuracy and diagnostic concordance with conventional pathology.

A new study found that the timing of small-bowel capsule endoscopy does not significantly affect detection rates of bleeding sources.

A prospective study has found that the Mediterranean diet may help reduce inflammation and support a healthier gut microbiome in newly diagnosed Crohn’s disease patients.

In patients with achalasia, esophageal Candida infection may be more than an incidental finding. A new study reveals it significantly increases the risk of developing esophageal cancer.

A large randomized clinical trial suggests that adults with uncomplicated appendicitis can safely wait for surgery without receiving antibiotics.

A study has found that H. pylori infection in gastric cancer is linked to reduced tumour-infiltrating lymphocytes and poorer patient outcomes.

Combining gelatin sponge with NBCA glue proved most effective in stopping arterial gastrointestinal bleeding, significantly outperforming sponge alone or with microcoils.

A Vietnamese study finds that a new mean nocturnal baseline impedance threshold of 1500 Ohms improves diagnostic precision for acid reflux disease.

Read about how mirikizumab shows strong results for IBD, improving remission and response rates.

Results from the phase 3 QUASAR trials show that guselkumab offers effective and safe induction and maintenance therapy for moderate-to-severe ulcerative colitis, with nearly 50% of patients achieving clinical remission after one year.

Pregnant individuals with IBD prescribed low-dose aspirin were no more likely to experience flares than those not on aspirin, according to a new study, easing concerns about its use in this high-risk population.

A new analysis from nearly 20,000 participants in the U.S. NHANES study has identified the platelet-to-high-density lipoprotein ratio (PHR) as a strong predictor of gastrointestinal cancer risk.

Tirzepatide linked to more GI issues than semaglutide in new study on weight-loss drugs without diabetes. Read more!

While both bariatric surgeries aid weight loss and quality of life, Roux-en-Y gastric bypass shows greater benefits for reducing acid reflux and oesophageal inflammation.

Research shows that compounds produced during cabbage fermentation protect gut lining from cytokine damage, highlighting the potential of fermented foods in gut health.

A new umbrella meta-analysis finds strong evidence that probiotics, particularly multi-strain formulations, reduce the risk of necrotising enterocolitis (NEC) and death in preterm babies.

New data from Ontario reveals a concerning rise in alcohol-related gastrointestinal diseases among people aged 13 to 39, with young women showing the steepest increase.

Researchers report that a novel cap-assisted clip closure technique shortens procedure time without compromising safety in patients undergoing endoscopic tumour resection.

New research suggests matcha may offer greater protection than green tea against intestinal injury caused by gamma radiation, via the TAK1–TAB pathway.

A new study links high glycemic index and load diets with increased risk of pancreatic steatosis, while fibre intake appears protective.

A new mobile app is helping doctors adhere to colorectal cancer screening guidelines, reducing unnecessary colonoscopies while identifying high-risk patients needing intensive follow-up.

A large international study shows that intestinal ultrasound during pregnancy can reveal hidden inflammatory bowel disease activity, significantly improving prediction of complications like preterm birth and preeclampsia, beyond what clinical symptoms and lab tests can detect.

New findings from a decades-long study of over 470,000 adults show that higher calcium intake may significantly reduce the risk of colorectal cancer, regardless of whether it comes from dairy, non-dairy foods, or supplements.

A novel minimally invasive endoscopic technique has proven safe and effective in removing gastric fundal subepithelial lesions, including low-risk GISTs, according to a recent study.

A novel IgG-guided elimination diet shows potential in reducing abdominal pain in patients with irritable bowel syndrome.

A new study found that children with COVID-19 have a 25% higher risk of developing persistent gastrointestinal symptoms months after infection.

Despite the significant health burden, there are gaps in managing alcohol-related digestive diseases.

A new blood test, PAC-MANN-1, could dramatically improve early detection of pancreatic cancer, one of the deadliest malignancies.

Garlic intake has long been touted for its health benefits, but new research suggests it may increase the risk of atrophic gastritis in individuals with H. pylori infections.

A randomised controlled trial in Japan suggests that nature exposure in early childhood may reduce GI symptoms, lower stress levels, and enhance gut microbiota diversity.

Ursodeoxycholic acid (UDCA) may provide a safe and effective alternative to surgery for dissolving gallstones in patients who have undergone sleeve gastrectomy, according to a new study. Gallstones dissolved in 60% of patients treated with UDCA, with fewer hospitalisations and mild side effects.

New study finds taking weight-loss drug semaglutide before bariatric surgery doesn’t improve overall weight loss or safety outcomes.

A decade-long study reveals that Roux-en-Y gastric bypass offers better long-term weight loss and GERD control compared to sleeve gastrectomy in patients with severe obesity. The findings may influence surgical decision-making for obesity management.

A machine learning model using XGBoost has been shown to outperform traditional clinical risk scoring systems in predicting mortality risk for ICU patients with acute pancreatitis.

A multicenter study has identified key prognostic factors in high-risk GIST patients, including preoperative inflammatory markers, mitotic index, and adherence to imatinib therapy.

Study reveals gut microbiota families linked to FMT success in ulcerative colitis patients, offering early treatment insights.

A machine learning model has been developed to predict the need for temporary stoma formation after intestinal resection in Crohn’s disease patients.

Researchers have identified key biomarkers that could help distinguish between uncomplicated and complicated appendicitis, allowing for earlier and more accurate diagnosis. The study found that Red Cell Distribution Width (RDW), Mean Platelet Volume (MPV), and appendix diameter are reliable indicators of appendicitis severity.

A new blood test, PAC-MANN, shows promise for early detection of pancreatic cancer, improving treatment options and survival rates.

A new study suggests that infants who consume a high-fibre diet before their first birthday may have a significantly lower risk of developing celiac disease.

A new study in BMC Gastroenterology confirms that fecal calprotectin (FC) from ileostomy output is a highly sensitive biomarker for detecting small bowel inflammation in postoperative Crohn’s disease patients.

A groundbreaking multicenter clinical trial has found that a personalized elimination diet guided by an IBS-specific IgG antibody assay significantly reduces abdominal pain intensity and symptoms in IBS patients.

A new study highlights that IBD patients, especially those with ulcerative colitis, are at significantly higher risk of Clostridioides difficile infection (CDI).

A UK Biobank study has revealed that central obesity, measured by waist circumference and waist-to-hip ratio, may be a stronger predictor of colorectal cancer risk than BMI.

A major NHS study has found significant ethnic disparities in colorectal cancer diagnosis, with non-white patients more likely to develop early-onset CRC but less likely to be diagnosed through urgent referrals.

New research published in has identified highly specific gut microbiome signatures linked to non-alcoholic fatty liver disease (NAFLD).

A new study has found that combining probiotics with immune checkpoint inhibitors and chemotherapy significantly improves survival rates, intestinal health, and immune response in patients with metastatic colorectal cancer.

Adding high-dose intravenous vitamin C to standard chemotherapy significantly improves survival in patients with metastatic pancreatic cancer.

A new study has found that severe dysphagia significantly worsens survival rates in patients undergoing percutaneous endoscopic gastrostomy (PEG).

A recent study analysing data from the NHANES database (2007–2010) reveals a compelling link between oxidative balance and bowel health, with notable differences between men and women.

A large-scale study of over 540,000 women reveals the protective role of calcium and dairy against colorectal cancer while highlighting risks linked to alcohol and red meat consumption.

Adhering to the Mediterranean diet may improve outcomes in newly diagnosed Crohn’s disease by reducing inflammation and promoting a healthier gut microbiome, a new study reveals.

Wearable devices like Apple Watches, Fitbits, and Oura Rings could revolutionise inflammatory bowel disease (IBD) management.

A new meta-analysis has provided further insight into the effects of time-restricted eating combined with exercise on body composition.

A recent study highlights the long-term benefits of bariatric surgery in preventing the progression from pre-diabetes to Type 2 diabetes.

While AI-assisted colonoscopy improves adenoma detection rates, it also increases the detection of non-neoplastic lesions.

The sequence of biologic treatments in patients with inflammatory bowel disease significantly affects their risk of adverse clinical outcomes.

Tulisokibart, a TNF–like cytokine 1A monoclonal antibody, has demonstrated significant potential in inducing clinical remission in patients with ulcerative colitis.

A new integrative risk score predicts the risk of Crohn’s disease in healthy first-degree relatives of individuals with the disease.

The latest clinical guidelines from the American College of Gastroenterology (ACG) aim to improve the diagnosis and treatment of eosinophilic oesophagitis.

A centralised, mailed colorectal cancer screening programme significantly improved screening completion rates in federally qualified health centres.

The ALLEGRO trial aimed to determine whether 2% IV lidocaine could speed up the return of gut function following colon resection surgery.

Top-down treatment for newly diagnosed Crohn’s disease significantly outperforms the conventional accelerated step-up approach.