Nephrology

A new study identifies key predictors of successful renal replacement therapy weaning and introduces a bedside tool to guide ICU decision-making.

Greater chronic kidney disease severity, particularly proteinuria, is linked to increased risk of cognitive impairment, a large cohort study finds.

RAAS inhibitors reduce kidney failure risk and improve blood pressure control compared with calcium channel blockers in children with CKD, new real-world data show.

Interim results from the Phase III VISIONARY trial show that sibeprenlimab significantly reduced proteinuria and improved disease biomarkers in patients with IgA nephropathy.

A large UK study finds commonly used eGFR equations may overestimate kidney function, potentially delaying chronic kidney disease diagnosis and treatment.

A study suggests convection volume in haemodiafiltration may be tailored to patient weight and residual kidney function to optimise middle-molecule clearance.

A study of hospitalised patients with acute kidney injury shows that failing to recover creatinine within 10% of baseline at 3 months predicts worse 5-year kidney outcomes.

Sepsis may worsen or improve AKI survival depending on illness severity, new data suggest. Explore how risk reverses in the sickest patients. Read more.

Elevated red cell distribution width-to-platelet ratio predicts cardiac surgery-associated acute kidney injury and improves risk stratification.

Study finds high rates of cognitive impairment in haemodialysis patients, with poorer physical function seen in those with established cognitive decline.

More than half of surgical ICU patients developed postoperative acute kidney injury, with sepsis, trauma, and CKD among key risk factors.

GLP-1 receptor agonists were associated with lower dementia and Alzheimer’s risk in patients with type 2 diabetes and CKD stage 3 or later.

A nationwide cohort study finds higher rates of congenital malformations in babies born to mothers with chronic and end-stage kidney disease.

A global analysis of childhood CKD reveals rising adolescent incidence, widening health inequalities, and links between kidney replacement therapy access and reduced disease burden.

A large meta-analysis links reduced kidney function to higher Alzheimer’s disease blood biomarkers, suggesting renal health may affect interpretation of dementia tests.

A nationwide comparative study shows SGLT2 inhibitors lower long-term chronic kidney disease and acute kidney injury risk compared with GLP-1 receptor agonists.

Melatonin supplementation reduced inflammation and improved lipid profiles in children undergoing chronic haemodialysis, suggesting potential cardiovascular and antioxidant benefits.

A preliminary study suggests a plant-based low-protein diet may improve metabolic and inflammatory parameters and help prevent malnutrition–inflammation complex syndrome in adults with CKD.

Altered serum and urinary bile acids were identified in patients with advanced chronic kidney disease, with specific bile acids associated with declining kidney function.

ERA Registry data show rising kidney replacement therapy incidence and prevalence across Central and Eastern Europe, with wide national variation and limited COVID-19 impact.

Meta-analysis shows neutrophil to lymphocyte ratio is associated with higher risk and progression of diabetic nephropathy, supporting its potential use as an inflammatory biomarker in clinical practice.

In a multivariate Cox proportional hazards model, statin therapy was associated with a 52% relative reduction in the risk of death at 30 days.

39 studies involving 14 300 participants showed that patients with diabetic nephropathy had significantly elevated NLR levels compared to diabetic controls without nephropathy.

Kidney transplant recipients from socioeconomically disadvantaged neighbourhoods face important inequalities in cancer risk and outcomes…

Starting dialysis with a less intensive schedule may help preserve remaining kidney function without increasing risks, according to a new study comparing dialysis approaches.

This study reports early outcomes of percutaneous kidney-sparing surgery for upper tract urothelial carcinoma, highlighting feasibility, recurrence rates, and follow-up needs.

A major clinical trial shows high-dose fish oil significantly reduces cardiovascular events in haemodialysis patients, offering a promising new preventive strategy.

A major clinical trial shows that a conservative, indication-based dialysis strategy improves kidney recovery and reduces complications in acute kidney injury.

GLP-1RA use lowered cardiovascular, kidney, and mortality risks in patients with lupus and diabetes

A large UK study has shown that novel biomarkers reflecting kidney damage, fibrosis, inflammation, and cardiovascular disease can predict kidney failure and all-cause mortality in chronic kidney disease (CKD) with accuracy similar to established clinical risk factors.

A pilot randomized trial found sodium bicarbonate therapy modestly improved cognitive scores in older patients with CKD and metabolic acidosis, though these gains weren’t significantly better than placebo.

Learn how EGF and UMOD levels may predict diabetic kidney disease progression, offering new tools for clinical risk assessment.

New research uncovers a potential kidney origin for Parkinson’s disease, challenging the idea that it begins in the brain and revealing a new disease pathway.

Presented at ERA 2025, this multicentre study identifies three immune subtypes of checkpoint inhibitor–induced nephritis, linking them to clinical outcomes and treatment responses.

A post-hoc analysis of the CANVAS trial reveals a dose-dependent cardiovascular benefit with canagliflozin in type 2 diabetes, while kidney protection appears consistent across doses.

Pegcetacoplan demonstrated a significant reduction in proteinuria and signs of kidney damage in patients with C3G or IC-MPGN and nephrotic-range proteinuria, according to VALIANT Phase 3 results.

In a landmark trial, IVIG therapy was shown to slow kidney function decline and tissue damage in patients with chronic active antibody-mediated rejection.

Selected as a top 10 abstract at the ERA Congress, this study unveils a new multiple biomarker model to predict tubulointerstitial fibrosis in IgA nephropathy without a biopsy.

Offspring of mothers who experienced preeclampsia during term pregnancies face higher long-term risks of kidney disease, according to a nationwide Danish study.

A new study highlights how combining the Geriatric Nutritional Risk Index (GNRI) and Modified Creatinine Index (mCI) significantly improves prediction of functional dependence in hemodialysis patients.

Researchers developed a machine learning model combining predictive power and interpretability to help manage hospital readmissions after kidney transplants.

GLP-1 receptor agonists were associated with nearly 50% lower graft loss and significantly reduced mortality in kidney transplant recipients with diabetes, according to new research.

Food insecurity may not raise overall hospitalization rates for adults on dialysis, but it triples the risk of fluid or electrolyte-related admissions, especially in younger patients, new research suggests.

Patients who develop hyponatremia after beginning thiazide diuretics face nearly double the risk of death, according to a new study. The research highlights the need for careful monitoring of sodium levels in hypertensive patients taking these common medications.

A large-scale study in Taiwan has revealed that SGLT2 inhibitors significantly lower the risk of kidney failure in patients with Type 2 diabetes and CKD stage 5.

A new study from the University of Minnesota suggests that differences in how kidney function is measured in living kidney donors could have significant long-term implications.

A study using data from the SPRINT trial has linked even mild, reversible acute kidney injury (AKI) to a significantly higher risk of dementia and mild cognitive impairment (MCI) in older adults with cardiovascular risk factors.

A study has shown that controlling blood pressure through active ultrafiltration rather than antihypertensive drugs significantly improves survival rates among CKD patients undergoing hemodialysis or hemodiafiltration.

A new therapy combining daratumumab and tocilizumab offers hope for kidney transplant patients battling late antibody-mediated rejection.

Intensive blood pressure control reduces cardiovascular risks in CKD patients but may increase adverse events, new real-world study shows.

Neutrophil-to-lymphocyte ratio predicts early mortality in older dialysis patients, offering insights for personalised treatment planning.

Alpha blockers increase fracture risk in female CKD patients treated for voiding dysfunction, emphasising the need for cautious prescribing.

A recent study highlights a significant risk for fractures in women with chronic kidney disease using alpha blockers for voiding dysfunction.

SGLT-2 inhibitors significantly lower mortality and adverse events in diabetic kidney transplant recipients, study reveals.

Robot-assisted kidney transplants offer outcomes comparable to open surgery for high-risk ABO-incompatible cases, study finds.

Machine learning identifies key factors and predicts success in renal replacement therapy discontinuation for critically ill patients with acute kidney injury.

Kinesiophobia affects 69% of peritoneal dialysis patients, influenced by factors like fatigue and coping strategies.

Peritoneal dialysis patients show high antibody response to mRNA COVID-19 vaccines, study reveals.

Kidney donation may cause long-term changes in bone and mineral metabolism, highlighting the need for monitoring donors’ metabolic health over time.

A recent study assessed the acceptability of a palliative care intervention designed for older adults with chronic kidney disease.

Repeat kidney biopsies may play an essential role in managing lupus nephritis, particularly for patients whose disease transitions between proliferative and non-proliferative classes.

A recent study highlighting the impact of high pulse pressure on kidney outcomes in diabetic patients.

A recent trial aimed to identify the best possible dialysis treatment by comparing high-dose haemodiafiltration versus conventional high-flux haemodialysis

Adults with elevated levels of calcium and oxalate in their urine may be at a heightened risk for developing kidney stones, according to a new study.

Researchers have developed a machine learning-based algorithm to predict short-term survival outcomes in critically ill patients undergoing continuous renal replacement therapy.

A new study has provided new insights into the dietary habits of individuals with chronic kidney disease in the UK, underscoring the importance of personalised nutrition therapy.

New study reveals the link between childhood IgA vasculitis and allergic rhinitis or chronic rhinosinusitis

Kidney transplant recipients with diabetes, face a significantly higher risk of mortality following graft loss compared to those without diabetes

A recent study has illustrated the prognostic role of the metabolic profile for predicting renal and cardiovascular endpoints in patients with IgA nephropathy.

Black adults may have significantly lower access to both deceased donor and live donor kidney transplants compared to White adults

A recent study has found that adults with class II to III obesity face an increased risk of poor cardiac outcomes, though they do not have a higher risk for kidney complications.

A recent analysis provides insights into gastrointestinal bleeding among patients with chronic kidney disease.

A risk prediction model for kidney injury in patients with cancer receiving chemotherapy has been developed.

A ground breaking study comparing non-surgical (medical) insertion of abdominal catheters for peritoneal dialysis to traditional surgical methods has unveiled promising results.

A recent cohort study on neonates reveals recurrent acute kidney injury (rAKI) risks and outcomes, stressing the need for vigilant monitoring and interventions post-initial AKI episode

A new study aimed to explore whether baseline kidney function, acute kidney disease severity, and post-AKD kidney function are associated with adverse outcomes in patients with AKI-D.

New research suggests that an integrated approach to deceased donor and kidney transplant services could significantly enhance the utilisation of deceased donor kidneys. Read now.

Estimating mortality due to kidney failure can be problematic, due to difficulties separating mortality attributed to comorbid conditions. Research has emerged which provides an alternative method to reduce this bias.

New research has noted an association between kidney cysts with progressive chronic kidney disease risk, following radical nephrectomy. Read to find out more.

According to study, donor nephrectomy in living kidney donors aged 70 years or older is safe, and does not significantly impact estimated glomerular filtration rate, or the risk of end-stage renal disease.

Acceptable options for the placement of peritoneal dialysis catheters now include advanced image-guided percutaneous and advanced laparoscopic techniques, according to a recent study.

A Canadian study has unveiled that an unhealthy microbiome, including a gut microbiome, is more likely to excrete toxins to the kidneys, leading to an increased formation of kidney stones.

A recent study in Israel revealed an association between high BMI in late adolescence and increased risk of chronic kidney disease (CKD) in young adults. Read more.

Percutaneous kidney biopsy has been shown to be a feasible and safe procedure when testing patients with small kidneys, according to new research. Read more.

New research, presented by Melandrea Worsley, Baylor College of Medicine, Houston, Texas, USA, and her team, suggests that racial and ethnic differences exist in arteriovenous access use in patients 1 year after haemodialysis initiation.

The study demonstrated a need for nephrologists to be better educated in recognising an association between CKD and menstrual abnormalities, as well as to communicate across disciplines to ensure patients are getting adequate care.

A new study shows that structured exercise routines and higher activity could help to slow down the decline in kidney function in older patients with chronic kidney disease, as well as improve their general health overall.

Previous research has shown an association between longer intervals of pre-operative haemodialysis and surgery and post-operative mortality, but the current study has provided new insights on socially vulnerable patients with end-stage kidney disease.

Patients with Type 1 diabetes who have received a kidney transplant may experience a reduced transplant failure risk, as well as a boost in life expectancy, following pancreatic islet transplantation, versus insulin alone.

Study suggests pregnant females with pre-eclampsia are at an increased risk of chronic hypertension, reduced kidney function, and albuminuria.

A research team investigated relationships between psychological distress and adherence to self-management recommendations in CKD…

We fondly remember John Mills MBE, patient advocate who was dedicated to raising awareness and improving care for patients with vasculitis.

A recent study has investigated the relationship between vegetable and fruit intake frequency and all-cause mortality in patients with chronic kidney disease. Read to find out more.

A recently developed aid, designed to help kidney patients understand their treatment options, including dialysis, conservative kidney management, and end-of-life planning, received positive feedback from older adults with the condition and their caregivers.

Kidneys transplanted from patients who tested positive for COVID-19 within 1 week of their death have been found to be safe to transplant.

Although vitamin B loss has been linked to haemodialysis, this has not been fully demonstrated consistently. Read more.

Researchers at SUNY Downstate University Hospital analysed deaths caused by various vascular complications in adults with diabetes. Read more.

Treating calciphylaxis with sodium thiosulfate has not been investigated in on peritoneal dialysis until now. Read more.

New research has found that patients with a poor nutritional status when beginning have an increased risk of death…

Approval of dapagliflozin for the treatment of chronic kidney disease has been confirmed by the National Institute of Health and Social Care Excellence…

The researchers discovered that although the virus enters, infects, and replicates in human kidney cells, this did not always lead to cell death…

Metabolites in the blood have been analysed, with their levels altered by coffee consumption, and an association with developing chronic kidney disease…

Frequent depressive symptoms have been linked to future rapid kidney decline in a study of adults with normal kidney function. Find out more

Low vitamin D in the blood has been associated with an increased risk of various diseases including Type 2 diabetes mellitus and kidney disease.