Oncology

Rucaparib showed longer progression-free survival, chemotherapy-free interval, and time to first subsequent treatment in advanced ovarian cancer patients, according to updated results from the ATHENA-MONO study.

ESGO 2025 study reveals overestimation of preoperative tumour size in stage IB2 cervical cancer, influencing adjuvant therapy decisions.

At the 2025 ESGO Annual Meeting, researchers unveiled two new diagnostic indices “Vienna Index” and “Top Vienna Index” which combine age with existing ovarian cancer biomarkers, significantly improving detection accuracy.

Study reveals a protein model to predict cardiomyopathy in childhood cancer survivors, enhancing early detection and intervention.

Aspirin was well-tolerated but did not significantly improve disease-free survival in high-risk colorectal cancer patients.

Personalised cancer vaccines show promise in preventing recurrence of high-risk kidney cancer, targeting key driver mutations.

U-Net neural network achieves 98.56% accuracy in brain tumour segmentation, promising advancements in neurological diagnostics and treatment planning.

Study reveals cancer survivors have lower dementia risk, suggesting potential shared biological mechanisms between cancer and neurodegeneration.

Study finds tumour-infiltrating lymphocytes linked to survival in early ERBB2-positive breast cancer, suggesting treatment de-escalation may be possible

New research reveals how aging rewires mammary gland cells, increasing breast cancer risk through epigenetic and immune changes.

Researchers uncover genetic variants that drive cancer risk, revealing new therapeutic targets and refining genetic screening strategies.

A new nomogram predicts microvascular invasion in patients with HCC, aiding preoperative decision-making and improving surgical outcomes.

New model enhances early detection of lymph node metastasis in breast cancer using CEUS images and machine learning.

A new study suggests that cannabidiol (CBD) may help reduce anxiety in women with advanced breast cancer undergoing tumour burden assessments.

AI and ML predict breast cancer recurrence and metastasis, offering new tools for better patient risk assessment and care.

Overexpression of RAD51 genes correlates with poorer prognosis in breast cancer, highlighting its potential as a prognostic biomarker and therapeutic target.

A groundbreaking study investigated repurposing the COVID-19 mRNA vaccine for cancer treatment.

Frequent polyp diagnoses in relatives significantly raise the risk of colorectal cancer, particularly for early-onset cases.

Research shows patients with vitiligo have no increased cancer risk, with reduced risks for melanoma, lung, and bladder cancers.

AI foundation models boost ovarian carcinoma subtyping accuracy, providing clinicians with valuable diagnostic support and efficiency.

A newly updated clinical practice guideline offers healthcare practitioners vital evidence-based recommendations for managing hepatitis B reactivation (HBVr) in individuals at risk.

A recent comprehensive study has offered new insights into the role of human epidermal growth factor 2 (HER2) in male breast cancer…

A recent study has revealed an increased risk of thyroid cancer diagnoses within the first year of starting GLP-1RA therapy.

A French study finds significant increases in digestive cancer risks, including small bowel, pancreatic, and gastric cancers, in celiac patients.

BRCA1/BRCA2 carriers face significantly higher risks of second cancers, including ovarian and pancreatic, after breast cancer.

A study suggests extending colonoscopy rescreening beyond 10 years for low-risk individuals, based on long-term colorectal cancer outcomes.

A new assessment scheme highlights the strengths and limitations of automatic tumour segmentation tools for glioblastoma on MRI.

A recent study has demonstrated the effectiveness of online screening and virtual patient education tools in improving hereditary cancer risk assessments

New compounds targeting PI3Kα show potential in treating triple-negative breast cancer, offering hope for more effective therapies.

Melanomas thicker than 0.8 mm significantly increase the risk of melanoma-related death, a study of over 144,000 patients shows.

A study has revealed that childhood obesity at the time of cancer diagnosis is associated with lower event-free survival and overall survival rates…

A new machine learning-based tool developed by researchers could revolutionise the way doctors diagnose tumours of unknown origin.

A recent study has uncovered a potential connection between environmental metal exposure and an increased risk of digestive tract cancers…

A study examining over 2,300 patients has unveiled promising new genomic biomarkers that could improve prognosis and treatment strategies for pancreatic ductal adenocarcinoma…

New research reveals the dual role of cancer-associated fibroblasts in tumour immunity, offering insights for future cancer therapies.

A recent study has highlighted a significant increase in the use of inpatient palliative care among metastatic testicular cancer patients undergoing critical care therapy between 2008 and 2019…

A recent study examining the effectiveness of a telemedicine-based exercise programme for cancer survivors has shown encouraging results…

A phase 3 clinical trial suggests that stereotactic body radiation therapy prior to systemic treatment may improve survival outcomes for patients with liver cancer.

Colorectal cancer incidence among adults under 50 years is rising in 27 of 50 countries analysed, according to a new global study.

A recent study evaluated the impact of a 3-month home-based exercise and self-management program on physical function in patients after lung resection surgery…

A recent study reveals that tumour upstaging in invasive melanoma occurs in 9.4% of cases and significantly worsens survival outcomes. Read more!

A new cohort study suggests that many men with suspected prostate cancer can safely avoid biopsies after receiving negative MRI results…

Researchers have identified the protein MYO1F as a key regulator of T cell metabolism, with implications for immune responses, cancer, and autoimmune diseases…

A recent study has shed light on improving the prognostication of Merkel cell carcinoma, a rare and aggressive form of skin cancer.

A new systematic review and meta-analysis highlights a significant link between elevated faecal haemoglobin levels and an increased risk of colorectal neoplasia.

This retrospective multicohort analysis, examined 95 patients who received ACT across various clinical trials from 2017 to 2023…

A groundbreaking study has demonstrated that AI-driven liquid biopsies could revolutionise cancer care…

The research aimed to assess the long-term risk of CRC based on colonoscopy screening results and demographic and lifestyle risk factors…

The study followed 18,463 high-risk smokers, who underwent pre-bronchodilator spirometry tests and were tracked over a median period of 6.1 years.

A groundbreaking study has identified a naturally occurring ligand derived from vitamin B6 that can activate immune cells to target tumours…

A recent study has explored the relationship between chronic pain and the risk of death from cerebrovascular disease in cancer patients…

A new study has explored the effectiveness of combining transpulmonary chemoembolisation and microwave ablation for treating non-small cell lung cancer…

A recent study has provided new insights into melanoma incidence and presentations among paediatric and adolescent and young adult patients.

A new study comparing treatment strategies for stage T2N0M0 oesophageal cancer has revealed no significant survival advantage for patients receiving neoadjuvant chemoradiotherapy followed by surgery.

A recent study from the REACT initiative highlights a significant gap in fertility preservation discussions for early-onset cancer patients, with nearly half reporting that they were not informed about fertility options before beginning treatment.

A new study reveals that combining proton beam therapy with boron neutron capture reactions increases its cell-killing effect, with higher boron concentrations yielding stronger therapeutic results…

Restaging MRI is a powerful tool for predicting survival and organ preservation in rectal cancer patients after total neoadjuvant therapy…

A new phase 3 trial (INTERLACE) shows that adding induction chemotherapy to standard chemoradiotherapy improves both progression-free and overall survival in patients with locally advanced cervical cancer.

A new study reveals how the m6A epitranscriptomic modification and MYCN oncogene cooperate to maintain an undifferentiated state in neuroblastoma…

Researchers have developed a novel treatment for non-small cell lung cancer (NSCLC) that uses customised antisense oligonucleotides (ASOs) to selectively target drug-resistant EGFR mutations.

A recent trial found that three cycles of CEV chemotherapy are as effective as six in treating high-risk unilateral retinoblastoma after enucleation.

A recent study uncovers genetic vulnerabilities in glioblastoma stem cells, pinpointing subtype-specific dependencies that drive tumour growth.

A recent study reveals that family members of cancer patients are at greater risk for developing psychological illnesses and cardiovascular diseases. The research highlights the need for better healthcare support for families coping with cancer.

A new clinical trial has found that extended lymphadenectomy does not improve disease-free or overall survival rates compared to standard lymphadenectomy in patients with localized muscle-invasive bladder cancer.

A recent analysis of the National Cancer Database reveals that health insurance plays a crucial role in racial and ethnic disparities in late-stage cancer diagnoses.

Socioeconomic factors influence prostate cancer test participation, with lower income and education linked to reduced uptake in organised screening programs.

Recent analysis from the National Cancer Database (NCDB) reveals a significant uptick in immunotherapy (IO) use for advanced kidney and bladder cancers….

A recent phase 3 trial has demonstrated that stereotactic body radiotherapy (SBRT) is a viable treatment for localised prostate cancer…

A study suggests that selenium, a mineral found in Brazil nuts, may hold the key to preventing the spread of triple negative breast cancer.

A pioneering breast cancer initiative is set to expand to Norfolk and Norwich University Hospital, providing more patients in the East with access to advanced, tailored treatment.

A review found no strong evidence linking radiofrequency electromagnetic fields from mobile phones and other sources to an increased risk of cancer, including brain tumours.

A new South Korean study reveals that patients with Graves’ disease, an autoimmune thyroid disorder, may have an increased risk of developing cancers

A recent study has identified key gene signatures that could help predict the efficacy of immune checkpoint blockade therapy in patients with metastatic melanoma.

A study finds that lower cardiopulmonary fitness is linked to more severe symptoms such as depression, poor sleep quality, and fatigue in newly diagnosed breast cancer patients.

A recent study has examined the potential link between the oral microbiome and the development of head and neck squamous cell cancer

In patients with primary thyroid cancer, there is an increased risk of melanoma and other non-keratinocyte skin cancers after radioactive iodine therapy.

A study has shown that modern radiotherapy techniques, including volumetric modulated arc therapy, significantly improve quality of life in head and neck cancer patients

A Swedish study has shown that total neoadjuvant treatment for locally advanced rectal cancer is effective in routine healthcare settings, offering similar results to the RAPIDO trial

A new study has highlighted shifting trends in head and neck cancers in Scotland, particularly focusing on the past two decades

Researchers have identified that Black women in the United States have significantly higher breast cancer mortality rates than White women

A new study has revealed that proteins found in foods such as meat and milk can help suppress the growth of tumours in the small intestines

A recent study explores serum anti-PD-1 autoantibodies as a potential biomarker for predicting survival outcomes in patients with advanced hepatocellular carcinoma

Researchers from Aston University, Birmingham, UK have developed a potential breakthrough treatment for osteosarcoma, the most common form of bone cancer.

A study on online adaptive radiotherapy reveals reduced treatment margins and lower radiation doses to organs at risk in gastric MALT lymphoma patients

A history of paediatric cancer has been linked to long-term cognitive challenges after treatment, affecting areas such as working memory and processing speed.

A groundbreaking clinical trial testing QH104, an allogeneic B7H3-targeting CAR-γδT cell therapy, has shown promising results for patients with recurrent glioblastoma.

A new study provides the first evidence that breastfeeding is safe for women with BRCA mutations after breast cancer treatment.

Results from the phase 3 ENGOT-cx11/GOG-3047/KEYNOTE-A18 study have been presented at ESMO 2024, Barcelona, Spain

The PEACE-3 trial shows that combining Enzalutamide with Radium-223 improves progression-free survival in metastatic castration-resistant prostate cancer.

New clinical trial results, presented at ESMO 2024, show that an investigational mRNA-based vaccine CVGBM is safe and well-tolerated in patient with newly diagnosed MGMT-unmethylated glioblastoma (GBM).

Researchers have made a significant breakthrough in understanding ductal carcinoma in situ, a pre-invasive tumour that can progress to invasive breast cancer.

A new study projects outcomes of breast cancer screening strategies using digital breast tomosynthesis with or without supplemental breast magnetic resonance imaging.

In a new, nonrandomised controlled trial, researchers have found that breast cancer risk was lower in individuals who had undergone bariatric surgery.

A study investigated academic readiness, its predictors, and its relationship with later academic performance in patients treated for CNS tumours during early childhood.

The Breast Cancer Index effectively predicts outcomes and benefits of ovarian function suppression therapy in premenopausal women with HR+ breast cancer.

Research shows annual mammograms lower late-stage breast cancer risk and improve survival compared to less frequent screening

Obesity is linked to improved survival outcomes in patients with head and neck squamous cell carcinoma treated with immune checkpoint inhibitors.

A new study found a significant link between chemotherapy-induced disruptions in the gut microbiome and cognitive decline in female patients with breast cancer.

A new study has uncovered a mechanism that drives the evolution of mismatch repair deficient colorectal cancer, a type of cancer known for its high mutation rates.

A recent study has shed light on the concerning link between high sugar consumption and premature aging in adult survivors of childhood cancer.

Recent findings indicate the potential cognitive benefits of hormone-modulating therapy for older women undergoing breast cancer treatment.

A recent study has cast doubt on the long-term mortality benefits of bilateral mastectomy for women with unilateral breast cancer.

Research highlights that aspirin use is associated with a significant reduction in colorectal cancer incidence, particularly among individuals with less healthy lifestyle habits.

New research reveals the impact of diet on the composition and function of our gut microbiome.

New research reveals lower breast cancer risk in women treated for ovarian cancer with BRCA mutations, particularly BRCA2.

Researchers conducted a prospective diagnostic study to explore whether differences in patients’ RAS variants reflected variance in the status of their tumours.

New research explores the link between endometriosis and ovarian cancer risk.

Electronic health record-based prompts have been shown to halve the rate of unnecessary surgery in older patients with early-stage breast cancer.

A new study stresses the importance of a universal screening and opt-out referral strategy that may mitigate disparities in tobacco treatment access and use in cancer care.

A new study highlights significant disparities in next-generation sequencing testing among patients with metastatic prostate cancer and advanced urothelial carcinoma.

A recent study showed that racial and ethnic minority groups have historically been underrepresented in clinical trials.

Researchers have highlighted a link between socioeconomic status and cardiovascular mortality.